Evaluation of 11 polycyclic aromatic hydrocarbon metabolites in urine of Czech mothers and newborns

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12110%2F17%3A43891118" target="_blank" >RIV/60076658:12110/17:43891118 - isvavai.cz</a>

Alternative codes found

RIV/68378041:_____/17:00481918 RIV/60461373:22330/17:43913807

Result on the web

<a href="http://dx.doi.org/10.1016/j.scitotenv.2016.10.165" target="_blank" >http://dx.doi.org/10.1016/j.scitotenv.2016.10.165</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.scitotenv.2016.10.165" target="_blank" >10.1016/j.scitotenv.2016.10.165</a>

Result language

angličtina

Original language name

Evaluation of 11 polycyclic aromatic hydrocarbon metabolites in urine of Czech mothers and newborns

Original language description

Polycyclic aromatic hydrocarbons (PAHs) represent a large group of ubiquitous contaminants of the environment, including food chain where they are released as by-products of incomplete combustion of an organic matter. Epidemiological studies have shown that exposure to PAHs correlated with increased incidence of cancer. Carcinogenicity is associated mainly with metabolites that are formed during metabolic degradation of these substances in exposed organism. In this study monohydroxylated PAHs (OH-PAH5), the major metabolites excreted into urine, were determined in 531 urine samples collected from mothers and their newborns from two localities of the Czech Republic - heavily air polluted Karvina and control locality of Ceske Budejovice and in two sampling rounds - August-October 2013 (summer, less air polluted season) and January-April 2014 (winter, more air polluted season). From all targeted analytes, naphthalene-2-ol was the most abundant compound present in 100% of the samples and it represented also the analyte with the highest concentration. Median concentration of Sigma OH-PAHs in the urine of children was on average 1.6 times lower compared to the respective mother which correlates with higher intake of PAHs by mothers. Sigma OH-PAHs concentrations determined in mothers' urine collected in the summer were comparable in both localities. No significant increase occurred in Ceske Budejovice in winter, while in samples from the Karvina region a statistically significant difference (alpha = 0.05) in the amount of Sigma OH-PAHs was observed. The median concentrations of Sigma OH-PAHs in mothers' urine samples in the winter were 1.5 times higher than in the summer in the same locality. The amounts of Sigma OH-PAHs in newborns' urine from Karvina in the winter season were 1.5 times higher than in the summer collected in the same locality and 3.3 times higher when compared with the less polluted locality of Ceske Budejovice.

Czech name

—

Czech description

—

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

DI - Pollution and air control

OECD FORD branch

—

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Science of the Total Environment

ISSN

0048-9697

e-ISSN

—

Volume of the periodical

577

Issue of the periodical within the volume

2017

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

8

Pages from-to

212-219

UT code for WoS article

000390737400021

EID of the result in the Scopus database

—