Impact of Air Pollution to the Oxidative Damage in Newborns

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22330%2F19%3A43919166" target="_blank" >RIV/60461373:22330/19:43919166 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Impact of Air Pollution to the Oxidative Damage in Newborns

Original language description

Background. The Northern Bohemia was from seventhies one of the most polluted region in Europe. Therefore the impact of air pollution was studied in newborns in the previously exposed district Most (M) and control district Ceske Budejovice (CB). Methods. Urine and cord blood from 100 newborns was collected in summer 2016-7 and winter 2017 in each district. Concentrations of c-PAHs (carcinogenic polycyclic aromatic hydrocarbons) were determined from HiVol samples of PM2.5. As biomarkers were determined oxidative damage by 8-oxodG adducts and monohydroxylated PAHs (OH-PAHs) in urine. Results. Concentrations of PM2.5 in summer were 11.22±5.13 g/m3 in M, 10.45±4.89 g/m3 in CB, in winter 25.12±24.46 g/m3 and 24.42±18.39 g/m3, respectively. Concentrations of B[a]P (benzo[a]pyrene) in summer were 0.25±0.53 ng/m3 in M, 0.29±0.0.60 ng/m3 in CB, in winter 0.87±0.81 ng/m3 and 1.20±1.36 ng/m3, respectively. 8-oxodG adducts (nmol/mmol creat.) in the urine of newborns in summer were 8.45±4.19 in M vs. 4.92±2.29 in CB (p&lt;0.001), in winter were 8.13±6.44 in M vs. 4.59±1.49 in CB (p&lt;0.001). The sum of OH-PAHs in newborn´s urine from M in the summer as well as winter season was significantly higher compared to CB (p&lt;0.001). Conclusions. No differences in air pollution were observed between two localities. Therefore, the higher oxidative damage and higher concentration of OH-PAHs in the urine of newborns in the district of Most seems to be peculiar. We may hypothesize, that previously exposed population is carrying some long term changes.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30304 - Public and environmental health

Project

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Continuities

R - Projekt Ramcoveho programu EK

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

ISSN

0893-6692

e-ISSN

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Volume of the periodical

60

Issue of the periodical within the volume

1-SI

Country of publishing house

US - UNITED STATES

Number of pages

1

Pages from-to

75

UT code for WoS article

000485250700173

EID of the result in the Scopus database

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