Early Diagnosis of Tularemia by Flow Cytometry, Czech Republic, 2003–2015
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12110%2F19%3A43899313" target="_blank" >RIV/60076658:12110/19:43899313 - isvavai.cz</a>
Result on the web
<a href="https://wwwnc.cdc.gov/eid/article/25/10/18-1875_article" target="_blank" >https://wwwnc.cdc.gov/eid/article/25/10/18-1875_article</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3201/eid2510.181875" target="_blank" >10.3201/eid2510.181875</a>
Alternative languages
Result language
angličtina
Original language name
Early Diagnosis of Tularemia by Flow Cytometry, Czech Republic, 2003–2015
Original language description
We retrospectively assessed the utility of a flow cytometry–based test quantifying the percentage of CD3+ T cells with the CD4–/CD8– phenotype for predicting tularemia diagnoses in 64 probable and confirmed tularemia patients treated during 2003–2015 and 342 controls with tularemia-like illnesses treated during 2012–2015 in the Czech Republic. The median percentage of CD3+/CD4–/CD8– T cells in peripheral blood was higher in tularemia patients (19%, 95% CI 17%–22%) than in controls (3%, 95% CI 2%–3%). When we used 8% as the cutoff, this test’s sensitivity was 0.953 and specificity 0.895 for distinguishing cases from controls. The CD3+/CD4–/CD8– T cells increased a median of 7 days before tularemia serologic test results became positive. This test supports early presumptive diagnosis of tularemia for clinically suspected cases 7–14 days before diagnosis can be confirmed by serologic testing in regions with low prevalences of tularemia-like illnesses.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
20602 - Medical laboratory technology (including laboratory samples analysis; diagnostic technologies) (Biomaterials to be 2.9 [physical characteristics of living material as related to medical implants, devices, sensors])
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Emerging Infectious Diseases
ISSN
1080-6040
e-ISSN
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Volume of the periodical
25
Issue of the periodical within the volume
10
Country of publishing house
US - UNITED STATES
Number of pages
9
Pages from-to
1919-1927
UT code for WoS article
000490017300016
EID of the result in the Scopus database
2-s2.0-85072396220