Cyclosporine A: Chemistry and Toxicity – A Review
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12110%2F21%3A43901356" target="_blank" >RIV/60076658:12110/21:43901356 - isvavai.cz</a>
Alternative codes found
RIV/62690094:18470/21:50018167 RIV/00179906:_____/21:10430032
Result on the web
<a href="https://www.eurekaselect.com/186667/article" target="_blank" >https://www.eurekaselect.com/186667/article</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.2174/0929867327666201006153202" target="_blank" >10.2174/0929867327666201006153202</a>
Alternative languages
Result language
angličtina
Original language name
Cyclosporine A: Chemistry and Toxicity – A Review
Original language description
Cyclosporine A (CsA) is a cyclic undecapeptide with strong immunosuppressive potency. Firstly marketed in the mid-1980s, CsA was widely used in transplantation and greatly improved the survival rates of patients and grafts after solidorgan transplantation. Unfortunately, CsA administration can be associated with a number of side effects due to its high toxicity. These side effects seriously limited the clinical use of CsA. Therefore, it is important to understand the serious side effects of CsA in patients, especially in transplantation. In this review article, we are summarizing the chemistry and most known toxic effects of CsA including the nephrotoxic, hepatotoxic, neurotoxic and cardiotoxic effects. Its available toxicity data (different species, different administration routes) published formerly are also summarized. In addition, the molecular pathways of toxic damage induced by CsA are also detailly discussed. We hope that this review will help to further understand the source, chemistry and clinical application of CsA in patients as well as the potential mechanisms of CsA-induced toxicity.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30107 - Medicinal chemistry
Result continuities
Project
<a href="/en/project/GA17-19968S" target="_blank" >GA17-19968S: Localized Electronic Effects of Antibody Binding on NanoComposite Materials (LEEFAB)</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Current Medicinal Chemistry
ISSN
0929-8673
e-ISSN
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Volume of the periodical
28
Issue of the periodical within the volume
20
Country of publishing house
AE - UNITED ARAB EMIRATES
Number of pages
10
Pages from-to
3925-3934
UT code for WoS article
000680008900003
EID of the result in the Scopus database
2-s2.0-85109117514