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Cyclosporine A: Chemistry and Toxicity – A Review

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12110%2F21%3A43901356" target="_blank" >RIV/60076658:12110/21:43901356 - isvavai.cz</a>

  • Alternative codes found

    RIV/62690094:18470/21:50018167 RIV/00179906:_____/21:10430032

  • Result on the web

    <a href="https://www.eurekaselect.com/186667/article" target="_blank" >https://www.eurekaselect.com/186667/article</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.2174/0929867327666201006153202" target="_blank" >10.2174/0929867327666201006153202</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Cyclosporine A: Chemistry and Toxicity – A Review

  • Original language description

    Cyclosporine A (CsA) is a cyclic undecapeptide with strong immunosuppressive potency. Firstly marketed in the mid-1980s, CsA was widely used in transplantation and greatly improved the survival rates of patients and grafts after solidorgan transplantation. Unfortunately, CsA administration can be associated with a number of side effects due to its high toxicity. These side effects seriously limited the clinical use of CsA. Therefore, it is important to understand the serious side effects of CsA in patients, especially in transplantation. In this review article, we are summarizing the chemistry and most known toxic effects of CsA including the nephrotoxic, hepatotoxic, neurotoxic and cardiotoxic effects. Its available toxicity data (different species, different administration routes) published formerly are also summarized. In addition, the molecular pathways of toxic damage induced by CsA are also detailly discussed. We hope that this review will help to further understand the source, chemistry and clinical application of CsA in patients as well as the potential mechanisms of CsA-induced toxicity.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30107 - Medicinal chemistry

Result continuities

  • Project

    <a href="/en/project/GA17-19968S" target="_blank" >GA17-19968S: Localized Electronic Effects of Antibody Binding on NanoComposite Materials (LEEFAB)</a><br>

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2021

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Current Medicinal Chemistry

  • ISSN

    0929-8673

  • e-ISSN

  • Volume of the periodical

    28

  • Issue of the periodical within the volume

    20

  • Country of publishing house

    AE - UNITED ARAB EMIRATES

  • Number of pages

    10

  • Pages from-to

    3925-3934

  • UT code for WoS article

    000680008900003

  • EID of the result in the Scopus database

    2-s2.0-85109117514