A possible link between cognitive development in 5 years old children and prenatal oxidative stress

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12110%2F22%3A43905234" target="_blank" >RIV/60076658:12110/22:43905234 - isvavai.cz</a>
Result on the web
<a href="https://www.nel.edu/userfiles/articlesnew/1659462225_43_1_blazkova_27-pdf.pdf" target="_blank" >https://www.nel.edu/userfiles/articlesnew/1659462225_43_1_blazkova_27-pdf.pdf</a>
DOI - Digital Object Identifier
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Result language
angličtina
Original language name
A possible link between cognitive development in 5 years old children and prenatal oxidative stress
Original language description
To study the impact of oxidative damage associated with particulate matter< 2.5 μm (PM2.5) during prenatal period on the cognitive development in five years old children. METHODS: Two cohorts of children aged five years, born in the years 2013 and 2014, were studied for their cognitive development in the polluted district Karvina and the control district Ceske Budejovice. Exposure to PM2.5 in the ambient air was measured for each mother during the 3 rd trimester of pregnancy. Oxidative damage was determined from the level of biomarkers at delivery in mothers ́and newborns ́ urine as 8-oxo-7,8-dihydro-2 ́-deoxyguanosine (8-oxodG) and in plasma as 15-F2t-isoprostane levels (15-F2t-IsoP). The Bender Visual Motor Gestalt Test (BG test) and the Raven Colored Progressive Matrices (RCPM test) were used as psychological cognitive tests.RESULTS: Average concentrations of PM2.5 ± SD in the 3rd trimester of mothers ́pregnancies were 37.7 ± 14.7 μg/m 3 and 17.1 ± 4.8 μg/m 3 in Karvina and Ceske Budejovice, respectively (p < 0.001). The maternal level of 15-F2t-IsoP in plasma at the time of delivery was significantly associated with the results of the RCPM test (p < 0.05) and the BG test (p < 0.05) in five years old children.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30304 - Public and environmental health

Project
<a href="/en/project/NV18-09-00151" target="_blank" >NV18-09-00151: Impact of air pollution to the morbidity in children</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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