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End-product inhibition of skatole-metabolising enzymes CYP1A, CYP2A19 and CYP2E1 in porcine and piscine hepatic microsomes

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12220%2F19%3A43899038" target="_blank" >RIV/60076658:12220/19:43899038 - isvavai.cz</a>

  • Alternative codes found

    RIV/60076658:12520/19:43899038

  • Result on the web

    <a href="https://www.sciencedirect.com/science/article/pii/S037842741832071X" target="_blank" >https://www.sciencedirect.com/science/article/pii/S037842741832071X</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1016/j.toxlet.2018.12.017" target="_blank" >10.1016/j.toxlet.2018.12.017</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    End-product inhibition of skatole-metabolising enzymes CYP1A, CYP2A19 and CYP2E1 in porcine and piscine hepatic microsomes

  • Original language description

    The hepatic cytochrome p450 enzymes 1 A, 2A19 and 2E1 is very important for the elimination of skatole from the body of pigs. Impaired skatole metabolism, results in skatole accumulation, which give rise to off flavor of the meat. Several metabolites of skatole has been identified, however the role of these metabolites in the inhibition of the skatole metabolizing enzymes are not documented. Using microsomes from pigs and fish, we determined the ability of several skatole metabolites to inhibit CYP1 A, CYP2A19 and CYP2E1 dependent activity. Our results show that 2-aminoacetophenone is an inhibitor of porcine CYP2A19 and CYP2E1 activity, but not the piscine orthologues. In conclusion, there is species specific differences in the inhibition of CYP1 A and CYP2A19 dependent metabolism of probe substrates. This is relevant to the evaluation of different model systems and to the reduction of off flavor of meat.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10608 - Biochemistry and molecular biology

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2019

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Toxicology Letters

  • ISSN

    0378-4274

  • e-ISSN

  • Volume of the periodical

    303

  • Issue of the periodical within the volume

    neuveden

  • Country of publishing house

    IE - IRELAND

  • Number of pages

    5

  • Pages from-to

    67-71

  • UT code for WoS article

    000456000400008

  • EID of the result in the Scopus database

    2-s2.0-85059461224