Porcine cytochrome 2A19 and 2E1

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12520%2F19%3A43899041" target="_blank" >RIV/60076658:12520/19:43899041 - isvavai.cz</a>

Result on the web

<a href="https://onlinelibrary.wiley.com/doi/full/10.1111/bcpt.13121" target="_blank" >https://onlinelibrary.wiley.com/doi/full/10.1111/bcpt.13121</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/bcpt.13121" target="_blank" >10.1111/bcpt.13121</a>

Result language

angličtina

Original language name

Porcine cytochrome 2A19 and 2E1

Original language description

Cytochrome P450 (CYP) is a major group of enzymes, which conduct Phase I metabolism. Among commonly used animal models, the pig has been suggested as the most suitable model for investigating drug metabolism in human beings. Moreover, porcine CYP2A19 and CYP2E1 are responsible for the biotransformation of both endogenous and exogenous compounds such as 3-methylindole (skatole), sex hormones and food compounds. However, little is known about the regulation of porcine CYP2A19 and CYP2E1. In this MiniReview, we summarise the current knowledge about the regulation of porcine CYP2A19 and CYP2E1 by environmental, biological and dietary factors. Finally, we reflect on the need for further research, to clarify the interaction between active feed components and the porcine CYP system.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10608 - Biochemistry and molecular biology

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Basic &amp; Clinical Pharmacology &amp; Toxicology

ISSN

1742-7835

e-ISSN

—

Volume of the periodical

124

Issue of the periodical within the volume

1

Country of publishing house

US - UNITED STATES

Number of pages

8

Pages from-to

32-39

UT code for WoS article

000454711300004

EID of the result in the Scopus database

2-s2.0-85054513592