Canine perineal tumours and selected tumour markers

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12220%2F19%3A43900420" target="_blank" >RIV/60076658:12220/19:43900420 - isvavai.cz</a>
Result on the web
<a href="https://actavet.vfu.cz/media/pdf/actavet_2019088040419.pdf" target="_blank" >https://actavet.vfu.cz/media/pdf/actavet_2019088040419.pdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.2754/avb201988040419" target="_blank" >10.2754/avb201988040419</a>

Result language
angličtina
Original language name
Canine perineal tumours and selected tumour markers
Original language description
The most frequent canine perineal tumour is the perianal (gland) adenoma (also known as the circumanal adenoma or the hepatoid adenoma). Tumour markers are substances that are produced by the body in response to cancer, or may be produced by cancer itself. Carcinoembryonic antigen (CEA) and tissue polypeptide specific antigen (TPSA) are tumour antigens that are markers of carcinogenesis, with significantly elevated serum concentrations in the case of some types of tumours. In our study it has been proven that dogs with a perineal tumour (n = 35) had a mean value of CEA 0.69 ng·ml-1 compared to control dogs (n = 150) with 0.67 ng·ml-1 (P > 0.05). In TPSA dogs with perineal tumour, the mean value of TPSA was 15.86 IU·l-1 vs 13.92 IU·l-1 in the control dogs (P < 0.05). The results of the present study show that there is significant differences in TPSA between control dogs and group of dogs with a perineal tumour. Analysis of oncomarkers is a valuable tool for practitioners within small animal oncology, having an advantage over tissue biomarkers as the measurement procedure is non-invasive and shows dynamic changes of physiological and pathological states before clinical signs appear. Therefore, it may be used for an early detection of cancer.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
40301 - Veterinary science

Project
<a href="/en/project/QK1910438" target="_blank" >QK1910438: Reduction the use of antibiotics by environmentally-friendly prebiotic and probiotic feed additives in the nutrition of calves</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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