A massive systematic infection of Encephalitozoon cuniculi genotype III in mice does not cause clinical signs

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12220%2F20%3A43901462" target="_blank" >RIV/60076658:12220/20:43901462 - isvavai.cz</a>
Alternative codes found
RIV/60077344:_____/20:00538180 RIV/60076658:12310/20:43901462
Result on the web
<a href="https://reader.elsevier.com/reader/sd/pii/S1286457920301222?token=BDF86F3F3F74304FAD3617497645DA9D771DA9559AFF49784652CDC14D97AD5837244C6DD96186B3ECE7972DD7B762C2" target="_blank" >https://reader.elsevier.com/reader/sd/pii/S1286457920301222?token=BDF86F3F3F74304FAD3617497645DA9D771DA9559AFF49784652CDC14D97AD5837244C6DD96186B3ECE7972DD7B762C2</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.micinf.2020.06.004" target="_blank" >10.1016/j.micinf.2020.06.004</a>

Result language
angličtina
Original language name
A massive systematic infection of Encephalitozoon cuniculi genotype III in mice does not cause clinical signs
Original language description
Encephalitozoon cuniculi genotype III disseminated intensively into most of the organs in all strains of mice, followed by a chronic infection with massive microsporidia persistence in immunodeficient mice and a partial decrease in C57Bl/6 mice. Treatment with 0.2 mg Albendazole/mouse/day temporarily reduces the number of affected organs in immunocompetent C57Bl/6 mice, but not in CD4(-/-) and CD8(-/-) mice. The application of medication temporarily decreased the spore burden at least by one order of magnitude in all groups. These results demonstrate that the E. cuniculi genotype III infection had a progressive course and surprisingly, Albendazole treatment had only a minimal effect. The E. cuniculi genotype III spore burden in individual organs reached up to 10(8) or 10(9) in immunocompetent or immunodeficient mice, respectively; however, these mice did not demonstrate any obvious clinical signs of microsporidiosis, and the immunodeficient mice survived longer. Our findings clearly show that the survival of mice does not correspond to spore burden, which provides new insight into latent microsporidiosis from an epidemiological point of view. (C) 2020 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30303 - Infectious Diseases

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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