The course of infection of Encephalitozoon cuniculi genotype I in mice possess combination of features reported in genotypes II and III
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12220%2F21%3A43903261" target="_blank" >RIV/60076658:12220/21:43903261 - isvavai.cz</a>
Alternative codes found
RIV/60076658:12310/21:43903261 RIV/60077344:_____/21:00554927
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S0014489421000382?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0014489421000382?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.exppara.2021.108101" target="_blank" >10.1016/j.exppara.2021.108101</a>
Alternative languages
Result language
angličtina
Original language name
The course of infection of Encephalitozoon cuniculi genotype I in mice possess combination of features reported in genotypes II and III
Original language description
Out of three genotypes of Encephalitozoon cuniculi (I-III) available for experimental studies, E. cuniculi genotype I remains the less characterized. This study describes for the first time individual phases of microsporidiosis caused by E. cuniculi genotype I and efficacy of albendazole treatment in immunocompetent BALB/c and C57Bl/6 mice and immunodeficient SCID, CD4(-/-) and CD8(-/-) mice using molecular detection and quantification methods. We demonstrate asymptomatic infection despite an intense dissemination of microsporidia into most organs within the first weeks post infection, followed by a chronic infection characterized by significant microsporidia persistence in immunocompetent, CD4(-/-) and CD8(-/-) mice and a lethal outcome for SCID mice. Albendazole application led to loss E. cuniculi genotype I infection in immunocompetent mouse strains, decreased spore burden by half in CD4(-/-) and CD8(-/-) mice, and prolongation of survival of SCID mice. These results showed Encephalitozoon cuniculi genotype I infection extend and albendazole sensitivity was comparable to E. cuniculi genotype II, but the infection onset speed and mortality rate was similar to E. cuniculi genotype III. These imply that differences in the course of infection and the response to treatment depend not only on immunological status of the host, but also on the genotype causing the infection.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10607 - Virology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Experimental Parasitology
ISSN
0014-4894
e-ISSN
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Volume of the periodical
224
Issue of the periodical within the volume
MAY 2021
Country of publishing house
US - UNITED STATES
Number of pages
10
Pages from-to
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UT code for WoS article
000642099500006
EID of the result in the Scopus database
2-s2.0-85103423580