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The course of infection of Encephalitozoon cuniculi genotype I in mice possess combination of features reported in genotypes II and III

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12220%2F21%3A43903261" target="_blank" >RIV/60076658:12220/21:43903261 - isvavai.cz</a>

  • Alternative codes found

    RIV/60076658:12310/21:43903261 RIV/60077344:_____/21:00554927

  • Result on the web

    <a href="https://www.sciencedirect.com/science/article/pii/S0014489421000382?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0014489421000382?via%3Dihub</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1016/j.exppara.2021.108101" target="_blank" >10.1016/j.exppara.2021.108101</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    The course of infection of Encephalitozoon cuniculi genotype I in mice possess combination of features reported in genotypes II and III

  • Original language description

    Out of three genotypes of Encephalitozoon cuniculi (I-III) available for experimental studies, E. cuniculi genotype I remains the less characterized. This study describes for the first time individual phases of microsporidiosis caused by E. cuniculi genotype I and efficacy of albendazole treatment in immunocompetent BALB/c and C57Bl/6 mice and immunodeficient SCID, CD4(-/-) and CD8(-/-) mice using molecular detection and quantification methods. We demonstrate asymptomatic infection despite an intense dissemination of microsporidia into most organs within the first weeks post infection, followed by a chronic infection characterized by significant microsporidia persistence in immunocompetent, CD4(-/-) and CD8(-/-) mice and a lethal outcome for SCID mice. Albendazole application led to loss E. cuniculi genotype I infection in immunocompetent mouse strains, decreased spore burden by half in CD4(-/-) and CD8(-/-) mice, and prolongation of survival of SCID mice. These results showed Encephalitozoon cuniculi genotype I infection extend and albendazole sensitivity was comparable to E. cuniculi genotype II, but the infection onset speed and mortality rate was similar to E. cuniculi genotype III. These imply that differences in the course of infection and the response to treatment depend not only on immunological status of the host, but also on the genotype causing the infection.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10607 - Virology

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2021

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Experimental Parasitology

  • ISSN

    0014-4894

  • e-ISSN

  • Volume of the periodical

    224

  • Issue of the periodical within the volume

    MAY 2021

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    10

  • Pages from-to

  • UT code for WoS article

    000642099500006

  • EID of the result in the Scopus database

    2-s2.0-85103423580