The course of infection caused by Encephalitozoon cuniculi genotype III in immunocompetent and immunodeficient mice

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F17%3A00479556" target="_blank" >RIV/60077344:_____/17:00479556 - isvavai.cz</a>
Alternative codes found
RIV/60076658:12220/17:43896919
Result on the web
<a href="http://dx.doi.org/10.1016/j.exppara.2017.09.022" target="_blank" >http://dx.doi.org/10.1016/j.exppara.2017.09.022</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.exppara.2017.09.022" target="_blank" >10.1016/j.exppara.2017.09.022</a>

Result language
angličtina
Original language name
The course of infection caused by Encephalitozoon cuniculi genotype III in immunocompetent and immunodeficient mice
Original language description
Encephalitozoon cuniculi is probably the most common microsporidia which infects a wide range of vertebrates, including human. So far, four genotypes of this parasite have been identified based on the rRNA internal transcribed spacer variations. The course of infection caused by E. cuniculi III had very massive onset in immunocompetent host characterized by the presence of this parasite in all organs and tissues within one week after peroral infection. Encephalitozoonosis caused by E. cuniculi III had very progressive spreading into all organs within first week post inoculation in immunocompromised SCID mice and led to the death of the host. The experimental treatment with albendazole of immunocompetent BALB/c mice infected with E. cuniculi III have shown very weak effect. Our findings clearly showed that the different course of infection and response to treatment depends not only on the immunological status of the host, but also on the genotype of microsporidia. It could be very important especially for individuals under chemotherapy and transplant recipients of organs originating from infected donors.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30303 - Infectious Diseases

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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