Changes in glucose-related parameters according to LDL-cholesterol concentration ranges in non-diabetic patients

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12220%2F25%3A43910246" target="_blank" >RIV/60076658:12220/25:43910246 - isvavai.cz</a>

Alternative codes found

RIV/60076658:12310/25:43910246 RIV/61989592:15110/25:73630636

Result on the web

<a href="https://jab.zsf.jcu.cz/artkey/jab-202501-0003_changes-in-glucose-related-parameters-according-to-ldl-cholesterol-concentration-ranges-in-non-diabetic-patient.php" target="_blank" >https://jab.zsf.jcu.cz/artkey/jab-202501-0003_changes-in-glucose-related-parameters-according-to-ldl-cholesterol-concentration-ranges-in-non-diabetic-patient.php</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.32725/jab.2025.005" target="_blank" >10.32725/jab.2025.005</a>

Result language

angličtina

Original language name

Changes in glucose-related parameters according to LDL-cholesterol concentration ranges in non-diabetic patients

Original language description

The study focused on the changes in C-peptide, glycemia, insulin concentration, and insulin resistance according to LDL-cholesterol concentration ranges. The metabolic profile of individuals in the Czech Republic (n = 1840) was classified by quartiles of LDL-cholesterol into four groups with the following ranges: 0.46-2.45 (n = 445), 2.46-3.00 (n = 474), 3.01-3.59 (n = 459), and 3.60-7.18 mmol/l (n = 462). The level of glucose, C-peptide, insulin, and area of parameters during OGTT and HOMA IR were compared with a relevant LDL-cholesterol range. The evaluation involved correlations between LDL-cholesterol and the above parameters, F-test and t-test. Generally, mean values of glucose homeostasis-related parameters were higher with increasing LDL-cholesterol levels, except for mean HOMA IR values which rapidly increased (2.7-3.4) between LDL-cholesterol ranges of 3.00-3.59 and 3.60-7.18 mmol/l. Glucose, C-peptide, insulin concentrations, and the area of parameters reached greater changes especially after glucose load during OGTT (p &lt;= 0.001). Considerable changes were already observed for the above parameters between groups with LDL-cholesterol ranges of 2.46-3.00 and 3.01-3.59 mmol/l. HOMA IR increased with higher LDL-cholesterol concentrations, but the differences in mean values were not statistically significant. Most important differences appeared in glucose metabolism at LDL-cholesterol concentrations of 3.60-7.18 mmol/l in comparison to LDL-cholesterol lower ranges. In particular, the areas of C-peptide, glucose, and insulin ranges showed statistically significant differences between all groups with growing LDL-cholesterol ranges. The variances of HOMA IR statistically differed between groups created according to LDL-cholesterol concentrations ranges.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30107 - Medicinal chemistry

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2025

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Applied Biomedicine

ISSN

1214-021X

e-ISSN

1214-0287

Volume of the periodical

23

Issue of the periodical within the volume

1

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

10

Pages from-to

26-35

UT code for WoS article

001454497600001

EID of the result in the Scopus database

2-s2.0-105001679321