The Changes of Cholesterol Profile at the Different Insulin Resistance Range in the Czech Republic
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62690094%3A18470%2F21%3A50018027" target="_blank" >RIV/62690094:18470/21:50018027 - isvavai.cz</a>
Alternative codes found
RIV/61989592:15110/21:73607519
Result on the web
<a href="https://www.mdpi.com/1648-9144/57/3/249" target="_blank" >https://www.mdpi.com/1648-9144/57/3/249</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/medicina57030249" target="_blank" >10.3390/medicina57030249</a>
Alternative languages
Result language
angličtina
Original language name
The Changes of Cholesterol Profile at the Different Insulin Resistance Range in the Czech Republic
Original language description
Background and Objectives: The mechanism of the relationship between glycemia and lipid metabolism has not been completely clarified, and slight differences may be found between authors and the kinds of evaluated parameters. Therefore, this study focused on possible changes of lipoprotein profile with regards to HOMA IR (Homeostatic Model Assessment for Insulin Resistance) cut-off 3.63, considered a signal of glucose metabolism alterations. Materials and Methods: The metabolic profiles of 3051 individuals were divided by HOMA IR values into two groups below cut-off 3.63, including (n = 2627) and above cut-off (n = 424). Patients taking medication or supplements to affect lipid, insulin, or glucose metabolism were excluded. Fasting glucose levels, insulin, and lipoproteins (total, HDL-high density and LDL-low density lipoprotein cholesterol) were compared between the groups with different HOMA IR. After analysis of data distribution, F-test and t-test were provided to compare variances and mean values. Results: The evaluation shows that the kind of cholesterol is crucial for a possible relationship with glucose metabolism and consequently confirms the changes of lipoproteins (HDL and LDL) by HOMA IR cut-off 3.63. Conclusions: The results of patients divided by HOMA IR cut-off 3.63 also suggest possible changes in the regulation of glucose metabolism and lipoprotein concentrations (HDL and LDL).
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
30202 - Endocrinology and metabolism (including diabetes, hormones)
Result continuities
Project
—
Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Medicina
ISSN
1010-660X
e-ISSN
—
Volume of the periodical
57
Issue of the periodical within the volume
3
Country of publishing house
CH - SWITZERLAND
Number of pages
9
Pages from-to
"Article number: 249"
UT code for WoS article
000633816200001
EID of the result in the Scopus database
2-s2.0-85103223860