Regulation of the transient receptor potential channel TRPA1 by its N-terminal ankyrin repeat domain

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12310%2F13%3A43883860" target="_blank" >RIV/60076658:12310/13:43883860 - isvavai.cz</a>
Alternative codes found
RIV/67179843:_____/12:00381621
Result on the web
<a href="http://link.springer.com/article/10.1007/s00894-012-1505-1" target="_blank" >http://link.springer.com/article/10.1007/s00894-012-1505-1</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s00894-012-1505-1" target="_blank" >10.1007/s00894-012-1505-1</a>

Result language
angličtina
Original language name
Regulation of the transient receptor potential channel TRPA1 by its N-terminal ankyrin repeat domain
Original language description
The transient receptor potential channel A1 (TRPA1) is unique among ion channels of higher vertebrates in that it harbors a large ankyrin repeat domain. The TRPA1 channel is expressed in the inner ear and in nociceptive neurons. It is involved in hearingas well as in the perception of pungent and irritant chemicals. The ankyrin repeat domain has special mechanical properties, which allows it to function as a soft spring that can be extended over a large range while maintaining structural integrity. A calcium-binding site has been experimentally identified within the ankyrin repeats. We built a model of the N-terminal 17 ankyrin repeat structure, including the calcium-binding EF-hand. In our simulations we find the calcium-bound state to be rigid as compared to the calcium-free state. While the end-to-end distance can change by almost 50% in the apo form, these fluctuations are strongly reduced by calcium binding. This increase in stiffness that constraints the end-to-end distance in t
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EI - Biotechnology and bionics
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach

Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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