Alga-based HPV16 E7 vaccine elicits specific immune response in mice

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12310%2F13%3A43885831" target="_blank" >RIV/60076658:12310/13:43885831 - isvavai.cz</a>
Result on the web
<a href="http://pelagiaresearchlibrary.com/asian-journal-of-plant-science/vol3-iss1/AJPSR-2013-3-1-141-148.pdf" target="_blank" >http://pelagiaresearchlibrary.com/asian-journal-of-plant-science/vol3-iss1/AJPSR-2013-3-1-141-148.pdf</a>
DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Alga-based HPV16 E7 vaccine elicits specific immune response in mice
Original language description
We engineered the chloroplasts of unicellular alga Chlamydomonas reinhardtii for the expression of human papillomavirus 16 oncoprotein E7, mutated for low oncogenicity and fused with aadA gene conferring spectinomycin resistance. The potential of transplastomic algae extracts as therapeutic vaccine against oncogenic papillomavirus infection was studied. Fusion protein could be detected in transplastomic algae together with its degradation products. Analysis of immune reactions induced in mice by vaccination with algae extracts showed high production of E7-specific antibodies, but low activation of E7-specific CD8+ cells.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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