The Importance of the 45 S Ribosomal Small Subunit-related Complex for Mitochondrial Translation in Trypanosoma brucei
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12310%2F13%3A43886533" target="_blank" >RIV/60076658:12310/13:43886533 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1074/jbc.M113.501874" target="_blank" >http://dx.doi.org/10.1074/jbc.M113.501874</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1074/jbc.M113.501874" target="_blank" >10.1074/jbc.M113.501874</a>
Alternative languages
Result language
angličtina
Original language name
The Importance of the 45 S Ribosomal Small Subunit-related Complex for Mitochondrial Translation in Trypanosoma brucei
Original language description
Background: Trypanosome mitochondria contain a 45 S ribosomal SSU-related complex with no precedence in other systems. Results: A selective ablation of the 45 S complex was associated with synthesis inhibition of some mitochondrial polypeptides. Conclusion: The 45 S complex is a factor required for mitochondrial translation that may have selective effects on different mRNAs. Significance: The mechanisms of mitochondrial translation in trypanosomes have no counterparts in other eukaryotes. The mitochondrial 45 S SSU* complex in Trypanosoma brucei contains the 9 S SSU ribosomal RNA, a set of SSU ribosomal proteins, several pentatricopeptide repeat (PPR) proteins, and proteins not typically found in ribosomes, including rhodanese domain protein (Rhod) anda 200-kDa coiled-coil protein. To investigate the function of this complex, PPR29, Rhod, 200-kDa protein, and mitochondrial ribosomal protein S17 were knocked down by RNAi in procyclic T. brucei. A growth retardation phenotype, a reducti
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
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Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Biological Chemistry
ISSN
0021-9258
e-ISSN
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Volume of the periodical
288
Issue of the periodical within the volume
46
Country of publishing house
US - UNITED STATES
Number of pages
16
Pages from-to
32963-32978
UT code for WoS article
000328841700014
EID of the result in the Scopus database
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