Dissociated G alpha(GTP) and G beta gamma Protein Subunits Are the Major Activated Form of Heterotrimeric Gi/o Proteins

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12310%2F14%3A43887351" target="_blank" >RIV/60076658:12310/14:43887351 - isvavai.cz</a>

Result on the web

<a href="http://www.jbc.org/content/289/3/1271.full" target="_blank" >http://www.jbc.org/content/289/3/1271.full</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1074/jbc.M113.493643" target="_blank" >10.1074/jbc.M113.493643</a>

Result language

angličtina

Original language name

Dissociated G alpha(GTP) and G beta gamma Protein Subunits Are the Major Activated Form of Heterotrimeric Gi/o Proteins

Original language description

The nature of the activated form of heterotrimeric Gi/o proteins is unclear.Non-modified Gi/o heterotrimers dissociate upon activation, whereas fluorescently labeled Gi/o heterotrimers dissociate or rearrange depending on fluorescent protein localization.Dissociated G(GTP) and G subunits represent the major activated form of Gi/o proteins.The identification of the Gi/o protein activated form is crucial for the elucidation of signaling mechanisms and rational drug design. Although most heterotrimeric G proteins are thought to dissociate into G and G subunits upon activation, the evidence in the Gi/o family has long been inconsistent and contradictory.The Gi/o protein family mediates inhibition of cAMP production and regulates the activity of ion channels. On the basis of experimental evidence, both heterotrimer dissociation and rearrangement have been postulated as crucial steps of Gi/o protein activation and signal transduction. We have now investigated the process of Gi/o activation i

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CE - Biochemistry

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Biological Chemistry

ISSN

0021-9258

e-ISSN

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Volume of the periodical

289

Issue of the periodical within the volume

3

Country of publishing house

US - UNITED STATES

Number of pages

11

Pages from-to

1271-1281

UT code for WoS article

000332401700007

EID of the result in the Scopus database

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