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Integrity of the core mitochondrial RNA-binding complex 1 is vital for trypanosome RNA editing

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12310%2F15%3A43888752" target="_blank" >RIV/60076658:12310/15:43888752 - isvavai.cz</a>

  • Result on the web

    <a href="http://rnajournal.cshlp.org/content/21/12/2088" target="_blank" >http://rnajournal.cshlp.org/content/21/12/2088</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1261/rna.052340.115" target="_blank" >10.1261/rna.052340.115</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Integrity of the core mitochondrial RNA-binding complex 1 is vital for trypanosome RNA editing

  • Original language description

    Trypanosoma brucei is the causative agent of the human and veterinarian diseases African sleeping sickness and nagana. A majority of its mitochondrial-encoded transcripts undergo RNA editing, an essential process of post-transcriptional uridine insertionand deletion to produce translatable mRNA. Besides the well-characterized RNA editing core complex, the mitochondrial RNA-binding 1 (MRB1) complex is one of the key players. It comprises a core complex of about six proteins, guide RNA-associated proteins (GAPs) 1/2, which form a heterotetramer that binds and stabilizes gRNAs, plus MRB5390, MRB3010, and MRB11870, which play roles in initial stages of RNA editing, presumably guided by the first gRNA:mRNA duplex in the case of the latter two proteins. Tobetter understand all functions of the MRB1 complex, we performed a functional analysis of the MRB8620 core subunit, the only one not characterized so far. Here we show that MRB8620 plays a role in RNA editing in both procyclic and bloods

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    EB - Genetics and molecular biology

  • OECD FORD branch

Result continuities

  • Project

  • Continuities

    S - Specificky vyzkum na vysokych skolach

Others

  • Publication year

    2015

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    RNA-A Publication of the RNA Society

  • ISSN

    1355-8382

  • e-ISSN

  • Volume of the periodical

    21

  • Issue of the periodical within the volume

    12

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    15

  • Pages from-to

    2088-2102

  • UT code for WoS article

    000365149900009

  • EID of the result in the Scopus database