Integrity of the core mitochondrial RNA-binding complex 1 is vital for trypanosome RNA editing
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12310%2F15%3A43888752" target="_blank" >RIV/60076658:12310/15:43888752 - isvavai.cz</a>
Result on the web
<a href="http://rnajournal.cshlp.org/content/21/12/2088" target="_blank" >http://rnajournal.cshlp.org/content/21/12/2088</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1261/rna.052340.115" target="_blank" >10.1261/rna.052340.115</a>
Alternative languages
Result language
angličtina
Original language name
Integrity of the core mitochondrial RNA-binding complex 1 is vital for trypanosome RNA editing
Original language description
Trypanosoma brucei is the causative agent of the human and veterinarian diseases African sleeping sickness and nagana. A majority of its mitochondrial-encoded transcripts undergo RNA editing, an essential process of post-transcriptional uridine insertionand deletion to produce translatable mRNA. Besides the well-characterized RNA editing core complex, the mitochondrial RNA-binding 1 (MRB1) complex is one of the key players. It comprises a core complex of about six proteins, guide RNA-associated proteins (GAPs) 1/2, which form a heterotetramer that binds and stabilizes gRNAs, plus MRB5390, MRB3010, and MRB11870, which play roles in initial stages of RNA editing, presumably guided by the first gRNA:mRNA duplex in the case of the latter two proteins. Tobetter understand all functions of the MRB1 complex, we performed a functional analysis of the MRB8620 core subunit, the only one not characterized so far. Here we show that MRB8620 plays a role in RNA editing in both procyclic and bloods
Czech name
—
Czech description
—
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
—
Result continuities
Project
—
Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
RNA-A Publication of the RNA Society
ISSN
1355-8382
e-ISSN
—
Volume of the periodical
21
Issue of the periodical within the volume
12
Country of publishing house
US - UNITED STATES
Number of pages
15
Pages from-to
2088-2102
UT code for WoS article
000365149900009
EID of the result in the Scopus database
—