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Protease Inhibitors in Tick Saliva: The Role of Serpins and Cystatins in Tick-host-Pathogen Interaction

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12310%2F17%3A43895541" target="_blank" >RIV/60076658:12310/17:43895541 - isvavai.cz</a>

  • Alternative codes found

    RIV/60077344:_____/17:00479013

  • Result on the web

    <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5447049/" target="_blank" >https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5447049/</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.3389/fcimb.2017.00216" target="_blank" >10.3389/fcimb.2017.00216</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Protease Inhibitors in Tick Saliva: The Role of Serpins and Cystatins in Tick-host-Pathogen Interaction

  • Original language description

    The publication of the first tick sialome (salivary gland transcriptome) heralded a new era of research of tick protease inhibitors, which represent important constituents of the proteins secreted via tick saliva into the host. Three major groups of protease inhibitors are secreted into saliva: Kunitz inhibitors, serpins, and cystatins. Kunitz inhibitors are anti-hemostatic agents and tens of proteins with one or more Kunitz domains are known to block host coagulation and/or platelet aggregation. Serpins and cystatins are also anti-hemostatic effectors, but intriguingly, from the translational perspective, also act as pluripotent modulators of the host immune system. Here we focus especially on this latter aspect of protease inhibition by ticks and describe the current knowledge and data on secreted salivary serpins and cystatins and their role in tick-host-pathogen interaction triad. We also discuss the potential therapeutic use of tick protease inhibitors.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10608 - Biochemistry and molecular biology

Result continuities

  • Project

    <a href="/en/project/GJ16-07117Y" target="_blank" >GJ16-07117Y: Serpins from the salivary glands of Lyme disease vector, the tick Ixodes ricinus, and their role in the tick-host-pathogen interaction</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2017

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Frontiers in Cellular and Infection Microbiology

  • ISSN

    2235-2988

  • e-ISSN

  • Volume of the periodical

    7

  • Issue of the periodical within the volume

    MAY 29 2017

  • Country of publishing house

    CH - SWITZERLAND

  • Number of pages

    16

  • Pages from-to

  • UT code for WoS article

    000402106500001

  • EID of the result in the Scopus database