Protease Inhibitors in Tick Saliva: The Role of Serpins and Cystatins in Tick-host-Pathogen Interaction
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12310%2F17%3A43895541" target="_blank" >RIV/60076658:12310/17:43895541 - isvavai.cz</a>
Alternative codes found
RIV/60077344:_____/17:00479013
Result on the web
<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5447049/" target="_blank" >https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5447049/</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3389/fcimb.2017.00216" target="_blank" >10.3389/fcimb.2017.00216</a>
Alternative languages
Result language
angličtina
Original language name
Protease Inhibitors in Tick Saliva: The Role of Serpins and Cystatins in Tick-host-Pathogen Interaction
Original language description
The publication of the first tick sialome (salivary gland transcriptome) heralded a new era of research of tick protease inhibitors, which represent important constituents of the proteins secreted via tick saliva into the host. Three major groups of protease inhibitors are secreted into saliva: Kunitz inhibitors, serpins, and cystatins. Kunitz inhibitors are anti-hemostatic agents and tens of proteins with one or more Kunitz domains are known to block host coagulation and/or platelet aggregation. Serpins and cystatins are also anti-hemostatic effectors, but intriguingly, from the translational perspective, also act as pluripotent modulators of the host immune system. Here we focus especially on this latter aspect of protease inhibition by ticks and describe the current knowledge and data on secreted salivary serpins and cystatins and their role in tick-host-pathogen interaction triad. We also discuss the potential therapeutic use of tick protease inhibitors.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
<a href="/en/project/GJ16-07117Y" target="_blank" >GJ16-07117Y: Serpins from the salivary glands of Lyme disease vector, the tick Ixodes ricinus, and their role in the tick-host-pathogen interaction</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Frontiers in Cellular and Infection Microbiology
ISSN
2235-2988
e-ISSN
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Volume of the periodical
7
Issue of the periodical within the volume
MAY 29 2017
Country of publishing house
CH - SWITZERLAND
Number of pages
16
Pages from-to
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UT code for WoS article
000402106500001
EID of the result in the Scopus database
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