Serpins in Tick Physiology and Tick-Host Interaction
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F22%3A00558626" target="_blank" >RIV/60077344:_____/22:00558626 - isvavai.cz</a>
Alternative codes found
RIV/60076658:12310/22:43904788
Result on the web
<a href="https://www.frontiersin.org/articles/10.3389/fcimb.2022.892770/full" target="_blank" >https://www.frontiersin.org/articles/10.3389/fcimb.2022.892770/full</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3389/fcimb.2022.892770" target="_blank" >10.3389/fcimb.2022.892770</a>
Alternative languages
Result language
angličtina
Original language name
Serpins in Tick Physiology and Tick-Host Interaction
Original language description
Tick saliva has been extensively studied in the context of tick-host interactions because it is involved in host homeostasis modulation and microbial pathogen transmission to the host. Accumulated knowledge about the tick saliva composition at the molecular level has revealed that serine protease inhibitors play a key role in the tick-host interaction. Serpins are one highly expressed group of protease inhibitors in tick salivary glands, their expression can be induced during tick blood-feeding, and they have many biological functions at the tick-host interface. Indeed, tick serpins have an important role in inhibiting host hemostatic processes and in the modulation of the innate and adaptive immune responses of their vertebrate hosts. Tick serpins have also been studied as potential candidates for therapeutic use and vaccine development. In this review, we critically summarize the current state of knowledge about the biological role of tick serpins in shaping tick-host interactions with emphasis on the mechanisms by which they modulate host immunity. Their potential use in drug and vaccine development is also discussed.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Frontiers in Cellular and Infection Microbiology
ISSN
2235-2988
e-ISSN
2235-2988
Volume of the periodical
12
Issue of the periodical within the volume
MAY 19 2022
Country of publishing house
CH - SWITZERLAND
Number of pages
20
Pages from-to
892770
UT code for WoS article
000810934400001
EID of the result in the Scopus database
2-s2.0-85132080769