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The first cell-fate decision of mouse preimplantation embryo development: integrating cell position and polarity

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12310%2F17%3A43895653" target="_blank" >RIV/60076658:12310/17:43895653 - isvavai.cz</a>

  • Result on the web

    <a href="http://rsob.royalsocietypublishing.org/content/7/11/170210" target="_blank" >http://rsob.royalsocietypublishing.org/content/7/11/170210</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1098/rsob.170210" target="_blank" >10.1098/rsob.170210</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    The first cell-fate decision of mouse preimplantation embryo development: integrating cell position and polarity

  • Original language description

    During the first cell-fate decision of mouse preimplantation embryo development, a population of outer-residing polar cells is segregated from a second population of inner apolar cells to form two distinct cell lineages: the trophectoderm and the inner cell mass (ICM), respectively. Historically, two models have been proposed to explain how the initial differences between these two cell populations originate and ultimately define them as the two stated early blastocyst stage cell lineages. The &apos;positional&apos; model proposes that cells acquire distinct fates based on differences in their relative position within the developing embryo, while the &apos;polarity&apos; model proposes that the differences driving the lineage segregation arise as a consequence of the differential inheritance of factors, which exhibit polarized subcellular localizations, upon asymmetric cell divisions. Although these two models have traditionally been considered separately, a growing body of evidence, collected over recent years, suggests the existence of a large degree of compatibility. Accordingly, the main aimof this reviewis to summarize the major historical and more contemporarily identified events that define the first cell-fate decision and to place them in the context of both the originally proposed positional and polarity models, thus highlighting their functional complementarity in describing distinct aspects of the developmental programme underpinning the first cell-fate decision in mouse embryogenesis.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10608 - Biochemistry and molecular biology

Result continuities

  • Project

  • Continuities

    S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2017

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Open biology

  • ISSN

    2046-2441

  • e-ISSN

  • Volume of the periodical

    7

  • Issue of the periodical within the volume

    11

  • Country of publishing house

    GB - UNITED KINGDOM

  • Number of pages

    14

  • Pages from-to

  • UT code for WoS article

    000416599600016

  • EID of the result in the Scopus database