Effect of blood type on anti-alpha-Gal immunity and the incidence of infectious diseases

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12310%2F17%3A43895742" target="_blank" >RIV/60076658:12310/17:43895742 - isvavai.cz</a>

Alternative codes found

RIV/60077344:_____/17:00507415

Result on the web

<a href="https://www.nature.com/articles/emm2016164" target="_blank" >https://www.nature.com/articles/emm2016164</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/emm.2016.164" target="_blank" >10.1038/emm.2016.164</a>

Result language

angličtina

Original language name

Effect of blood type on anti-alpha-Gal immunity and the incidence of infectious diseases

Original language description

The identification of factors affecting the susceptibility to infectious diseases is essential toward reducing their burden on the human population. The ABO blood type correlates with susceptibility to malaria and other infectious diseases. Due to the structural similarity between blood antigen B and Gal alpha 1-3Gal beta 1-(3)4GlcNAc-R (alpha-Gal), we hypothesized that self-tolerance to antigen B affects the immune response to alpha-Gal, which in turn affects the susceptibility to infectious diseases caused by pathogens carrying alpha-Gal on their surface. Here we found that the incidence of malaria and tuberculosis, caused by pathogens with alpha-Gal on their surface, positively correlates with the frequency of blood type B in endemic regions. However, the incidence of dengue fever, caused by a pathogen without alpha-Gal, was not related to the frequency of blood type B in these populations. Furthermore, the incidence of malaria and tuberculosis was negatively correlated with the anti-alpha-Gal antibody protective response. These results have implications for disease control and prevention.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10608 - Biochemistry and molecular biology

Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Experimental and Molecular Medicine

ISSN

1226-3613

e-ISSN

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Volume of the periodical

49

Issue of the periodical within the volume

MAR 2017

Country of publishing house

US - UNITED STATES

Number of pages

7

Pages from-to

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UT code for WoS article

000397275000004

EID of the result in the Scopus database

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