Effect of blood type on anti-alpha-Gal immunity and the incidence of infectious diseases
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F17%3A00507415" target="_blank" >RIV/60077344:_____/17:00507415 - isvavai.cz</a>
Alternative codes found
RIV/60076658:12310/17:43895742
Result on the web
<a href="https://www.nature.com/articles/emm2016164" target="_blank" >https://www.nature.com/articles/emm2016164</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/emm.2016.164" target="_blank" >10.1038/emm.2016.164</a>
Alternative languages
Result language
angličtina
Original language name
Effect of blood type on anti-alpha-Gal immunity and the incidence of infectious diseases
Original language description
The identification of factors affecting the susceptibility to infectious diseases is essential toward reducing their burden on the human population. The ABO blood type correlates with susceptibility to malaria and other infectious diseases. Due to the structural similarity between blood antigen B and Gal alpha 1-3Gal beta 1-(3)4GlcNAc-R (alpha-Gal), we hypothesized that self-tolerance to antigen B affects the immune response to alpha-Gal, which in turn affects the susceptibility to infectious diseases caused by pathogens carrying alpha-Gal on their surface. Here we found that the incidence of malaria and tuberculosis, caused by pathogens with alpha-Gal on their surface, positively correlates with the frequency of blood type B in endemic regions. However, the incidence of dengue fever, caused by a pathogen without alpha-Gal, was not related to the frequency of blood type B in these populations. Furthermore, the incidence of malaria and tuberculosis was negatively correlated with the anti-alpha-Gal antibody protective response. These results have implications for disease control and prevention.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Experimental and Molecular Medicine
ISSN
1226-3613
e-ISSN
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Volume of the periodical
49
Issue of the periodical within the volume
MAR 2017
Country of publishing house
US - UNITED STATES
Number of pages
7
Pages from-to
e301
UT code for WoS article
000397275000004
EID of the result in the Scopus database
2-s2.0-85020575383