All

What are you looking for?

All
Projects
Results
Organizations

Quick search

  • Projects supported by TA ČR
  • Excellent projects
  • Projects with the highest public support
  • Current projects

Smart search

  • That is how I find a specific +word
  • That is how I leave the -word out of the results
  • “That is how I can find the whole phrase”

Effect of blood type on anti-alpha-Gal immunity and the incidence of infectious diseases

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F17%3A00507415" target="_blank" >RIV/60077344:_____/17:00507415 - isvavai.cz</a>

  • Alternative codes found

    RIV/60076658:12310/17:43895742

  • Result on the web

    <a href="https://www.nature.com/articles/emm2016164" target="_blank" >https://www.nature.com/articles/emm2016164</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1038/emm.2016.164" target="_blank" >10.1038/emm.2016.164</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Effect of blood type on anti-alpha-Gal immunity and the incidence of infectious diseases

  • Original language description

    The identification of factors affecting the susceptibility to infectious diseases is essential toward reducing their burden on the human population. The ABO blood type correlates with susceptibility to malaria and other infectious diseases. Due to the structural similarity between blood antigen B and Gal alpha 1-3Gal beta 1-(3)4GlcNAc-R (alpha-Gal), we hypothesized that self-tolerance to antigen B affects the immune response to alpha-Gal, which in turn affects the susceptibility to infectious diseases caused by pathogens carrying alpha-Gal on their surface. Here we found that the incidence of malaria and tuberculosis, caused by pathogens with alpha-Gal on their surface, positively correlates with the frequency of blood type B in endemic regions. However, the incidence of dengue fever, caused by a pathogen without alpha-Gal, was not related to the frequency of blood type B in these populations. Furthermore, the incidence of malaria and tuberculosis was negatively correlated with the anti-alpha-Gal antibody protective response. These results have implications for disease control and prevention.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10608 - Biochemistry and molecular biology

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2017

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Experimental and Molecular Medicine

  • ISSN

    1226-3613

  • e-ISSN

  • Volume of the periodical

    49

  • Issue of the periodical within the volume

    MAR 2017

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    7

  • Pages from-to

    e301

  • UT code for WoS article

    000397275000004

  • EID of the result in the Scopus database

    2-s2.0-85020575383