Remodeling of tick cytoskeleton in response to infection with Anaplasma phagocytophilum
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12310%2F17%3A43898154" target="_blank" >RIV/60076658:12310/17:43898154 - isvavai.cz</a>
Alternative codes found
RIV/00027162:_____/17:N0000085
Result on the web
<a href="https://www.bioscience.org/2017/v22/af/4574/fulltext.php?bframe=PDF" target="_blank" >https://www.bioscience.org/2017/v22/af/4574/fulltext.php?bframe=PDF</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.2741/4574" target="_blank" >10.2741/4574</a>
Alternative languages
Result language
angličtina
Original language name
Remodeling of tick cytoskeleton in response to infection with Anaplasma phagocytophilum
Original language description
The obligate intracellular pathogen Anaplasma phagocytophilum infects vertebrate and tick hosts. In this study, a genome-wide search for cytoskeleton components was performed in the tick vector, lxodes scapularis. The available transcriptomics and proteomics data was then used to characterize the mRNA and protein levels of I. scapularis cytoskeleton components in response to A. phagocytophilum infection. The results showed that cytoskeleton components described in other model organisms were present in the I. scapularis genome. One type of intermediate filaments (lamin), a family of septins that was recently implicated in the cellular response to intracellular pathogens, and several members of motor proteins (kinesins and dyneins) that could be implicated in the cytoplasmic movements of A. phagocytophilum were found. The results showed that levels of tubulin, actin, septin, actin-related proteins and motor proteins were affected by A. phagocytophilum, probably to facilitate infection in I. scapularis. Functional studies demonstrated a role for selected cytoskeleton components in pathogen infection. These results provided a more comprehensive view of the cytoskeletal components involved in the response to A. phagocytophilum infection in ticks.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10606 - Microbiology
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Frontiers of Bioscience
ISSN
1093-9946
e-ISSN
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Volume of the periodical
22
Issue of the periodical within the volume
JUN 1 2017
Country of publishing house
US - UNITED STATES
Number of pages
15
Pages from-to
1830-1844
UT code for WoS article
000439039200001
EID of the result in the Scopus database
2-s2.0-85027704584