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Remodeling of tick cytoskeleton in response to infection with Anaplasma phagocytophilum

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F17%3A00478939" target="_blank" >RIV/60077344:_____/17:00478939 - isvavai.cz</a>

  • Result on the web

    <a href="https://www.bioscience.org/2017/v22/af/4574/list.htm" target="_blank" >https://www.bioscience.org/2017/v22/af/4574/list.htm</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.2741/4574" target="_blank" >10.2741/4574</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Remodeling of tick cytoskeleton in response to infection with Anaplasma phagocytophilum

  • Original language description

    The obligate intracellular pathogen Anaplasma phagocytophilum infects vertebrate and tick hosts. In this study, a genome-wide search for cytoskeleton components was performed in the tick vector, Ixodes scapularis. The available transcriptomics and proteomics data was then used to characterize the mRNA and protein levels of I. scapularis cytoskeleton components in response to A. phagocytophilum infection. The results showed that cytoskeleton components described in other model organisms were present in the I. scapularis genome. One type of intermediate filaments (lamin), a family of septins that was recently implicated in the cellular response to intracellular pathogens, and several members of motor proteins (kinesins and dyneins) that could be implicated in the cytoplasmic movements of A. phagocytophilum were found. The results showed that levels of tubulin, actin, septin, actin-related proteins and motor proteins were affected by A. phagocytophilum, probably to facilitate infection in I. scapularis. Functional studies demonstrated a role for selected cytoskeleton components in pathogen infection. These results provided a more comprehensive view of the cytoskeletal components involved in the response to A. phagocytophilum infection in ticks.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10608 - Biochemistry and molecular biology

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2017

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Frontiers in Bioscience-Landmark

  • ISSN

    1093-4715

  • e-ISSN

  • Volume of the periodical

    22

  • Issue of the periodical within the volume

    Jun 1

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    15

  • Pages from-to

    1830-1844

  • UT code for WoS article

    000439039200001

  • EID of the result in the Scopus database

    2-s2.0-85027704584