Remodeling of tick cytoskeleton in response to infection with Anaplasma phagocytophilum

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F17%3A00478939" target="_blank" >RIV/60077344:_____/17:00478939 - isvavai.cz</a>

Result on the web

<a href="https://www.bioscience.org/2017/v22/af/4574/list.htm" target="_blank" >https://www.bioscience.org/2017/v22/af/4574/list.htm</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.2741/4574" target="_blank" >10.2741/4574</a>

Result language

angličtina

Original language name

Remodeling of tick cytoskeleton in response to infection with Anaplasma phagocytophilum

Original language description

The obligate intracellular pathogen Anaplasma phagocytophilum infects vertebrate and tick hosts. In this study, a genome-wide search for cytoskeleton components was performed in the tick vector, Ixodes scapularis. The available transcriptomics and proteomics data was then used to characterize the mRNA and protein levels of I. scapularis cytoskeleton components in response to A. phagocytophilum infection. The results showed that cytoskeleton components described in other model organisms were present in the I. scapularis genome. One type of intermediate filaments (lamin), a family of septins that was recently implicated in the cellular response to intracellular pathogens, and several members of motor proteins (kinesins and dyneins) that could be implicated in the cytoplasmic movements of A. phagocytophilum were found. The results showed that levels of tubulin, actin, septin, actin-related proteins and motor proteins were affected by A. phagocytophilum, probably to facilitate infection in I. scapularis. Functional studies demonstrated a role for selected cytoskeleton components in pathogen infection. These results provided a more comprehensive view of the cytoskeletal components involved in the response to A. phagocytophilum infection in ticks.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10608 - Biochemistry and molecular biology

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Frontiers in Bioscience-Landmark

ISSN

1093-4715

e-ISSN

—

Volume of the periodical

22

Issue of the periodical within the volume

Jun 1

Country of publishing house

US - UNITED STATES

Number of pages

15

Pages from-to

1830-1844

UT code for WoS article

000439039200001

EID of the result in the Scopus database

2-s2.0-85027704584