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Adipokinetic hormone and adenosine interfere with nematobacterial infection and locomotion in Drosophila melanogaster

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12310%2F18%3A43897407" target="_blank" >RIV/60076658:12310/18:43897407 - isvavai.cz</a>

  • Alternative codes found

    RIV/60077344:_____/18:00489356 RIV/00216224:14310/18:00100913

  • Result on the web

    <a href="https://reader.elsevier.com/reader/sd/pii/S0022191018300787?token=DE6D13E92A357D73805EF2EC4279838625701F67266BF7AB661E1494D2CA6C9A3A26DCC33E890E364012B34B3346FC90" target="_blank" >https://reader.elsevier.com/reader/sd/pii/S0022191018300787?token=DE6D13E92A357D73805EF2EC4279838625701F67266BF7AB661E1494D2CA6C9A3A26DCC33E890E364012B34B3346FC90</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1016/j.jinsphys.2018.04.002" target="_blank" >10.1016/j.jinsphys.2018.04.002</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Adipokinetic hormone and adenosine interfere with nematobacterial infection and locomotion in Drosophila melanogaster

  • Original language description

    This study examined how adipokinetic hormone (AKH) and adenosine affect defense responses in Drosophila melanogaster larvae infected with entomopathogenic nematodes (EPN, Steinernema carpocapsae and Heterorhabditis bacteriophora). Three loss-of-function mutant larvae were tested: Akh(1), AdoR(1) (adenosine receptor), and Akh(1) AdoR(1). Mortality decreased in all mutants post-EPN infection compared with the control (w(1118)). Additionally, co-application of external AKH with EPN significantly increased mortality beyond rates observed in EPN-only treatment, while also elevating carbon dioxide production, a measure of metabolism. Furthermore trehalose levels increased in both w(1118) and Akh(1) larvae post-EPN infection, but the latter group exhibited a lower increase and total trehalose levels. Interestingly, baseline trehalose was relatively high in untreated AdoR(1) and Akh(1) AdoR(1) mutants, with levels remaining unaffected by infection. Infection also elevated haemolymph lipid content overall, but the different mutations did not substantially influence this change. In contrast, haemolymph protein content dropped after EPN infection in all tested groups, but this decline was more intense among Akh(1). In uninfected larvae mutations decreased antioxidative capacity in Akh(1) and increased in AdoR(1), however, its post-infection increases were similar in all mutants, suggesting that antioxidant response in Drosophila involves mechanisms also beyond AKH and adenosine. Furthermore, AKH application in w(1118) larvae significantly increased movement distance and percentage of larval activity, but reduced velocity. Mutations of Akh and AdoR did not strongly affect locomotion.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10608 - Biochemistry and molecular biology

Result continuities

  • Project

    <a href="/en/project/GA17-03253S" target="_blank" >GA17-03253S: Hormonal control of insect defence system</a><br>

  • Continuities

    S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2018

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Journal of Insect Physiology

  • ISSN

    0022-1910

  • e-ISSN

  • Volume of the periodical

    107

  • Issue of the periodical within the volume

    MAY-JUN 2018

  • Country of publishing house

    GB - UNITED KINGDOM

  • Number of pages

    8

  • Pages from-to

    167-174

  • UT code for WoS article

    000434751100021

  • EID of the result in the Scopus database

    2-s2.0-85045386083