Defence reaction against nematobacterial infection in Drosophila melanogaster: a role for the adipokinetic hormone and adenosine

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F16%3A00090706" target="_blank" >RIV/00216224:14310/16:00090706 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Defence reaction against nematobacterial infection in Drosophila melanogaster: a role for the adipokinetic hormone and adenosine
Original language description
Entomopathogenic nematodes are multicellular insect parasites which are symbiotically associated with particular species of bacteria forming together highly pathogenic complex. This complex represents a severe stress for the infected insect that must activate its anti-stress defence system. It is supposed that adipokinetic hormone (AKH), important stress hormone responsible for keeping homeostasis in insect body, and adenosine, a purine nucleotide that serves as signalling factor in anti-stress reaction on both cellular and organismal levels, play a role in defence reaction against the infection. To verify this, the Drosophila melanogaster mutants producing (1) defect non-functional AKH (AKH-def) and (2) impaired adenosine receptor (AdoR-def), and two nematodal species Steinernema carpocapsae and Heterorhabditis bacteriophora were used in our study. The results revealed that both AKH-def and AdoR-def flies infected by the nematodes showed significantly lower mortality (1.9 and 1.
Czech name
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Czech description
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Project
<a href="/en/project/LH14047" target="_blank" >LH14047: Hormonal control of anti-stress reactions in insects</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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