Antiplasmodial activity of tick defensins in a mouse model of malaria

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12310%2F18%3A43897458" target="_blank" >RIV/60076658:12310/18:43897458 - isvavai.cz</a>

Alternative codes found

RIV/60077344:_____/18:00498052

Result on the web

<a href="https://reader.elsevier.com/reader/sd/pii/S1877959X17303291?token=C60F6E85BD768BFAE61AE1C0C36B4B9FF52CAAC5369C11076A66A2EF953A62FFDA0D60BEBBC2F9913FEC0AEC08AA899A" target="_blank" >https://reader.elsevier.com/reader/sd/pii/S1877959X17303291?token=C60F6E85BD768BFAE61AE1C0C36B4B9FF52CAAC5369C11076A66A2EF953A62FFDA0D60BEBBC2F9913FEC0AEC08AA899A</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.ttbdis.2018.03.011" target="_blank" >10.1016/j.ttbdis.2018.03.011</a>

Result language

angličtina

Original language name

Antiplasmodial activity of tick defensins in a mouse model of malaria

Original language description

Malaria is a mosquito-borne disease affecting millions of people mainly in Sub-Saharan Africa, Asia and some South American countries. Drug resistance to first-line antimalarial drugs (e.g. chloroquine, sulfadoxine-pyrimethamine and artemisinin) is a major constrain in malaria control. Antimicrobial peptides (AMPs) have shown promising results in controlling Plasmodium spp. parasitemia in in vitro and in vivo models of infection. Defensins are AMPs that act primarily by disrupting the integrity of cell membranes of invasive microbes. We previously showed that defensins from the tick Ixodes ricinus inhibited significantly the growth of P. falciparum in vitro, a property that was conserved during evolution. Here, we tested the activity of three I. ricinus defensins against P. chabaudi in mice. A single dose of defensin (120 mu l of 1 mg/ml solution) was administered intravenously to P. chabaudi-infected mice, and the parasitemia was followed for 24 h post-treatment. Defensin treatment inhibited significantly the replication (measured as increases in parasitemia) of P. chabaudi after 1 h and 12 h of treatment. Furthermore, defensin injection was not associated with toxicity. These results agreed with the previous report of antiplasmodial activity of tick defensins against P. falciparum in vitro and justify further studies for the use of tick defensins to control malaria.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10608 - Biochemistry and molecular biology

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Ticks and Tick-borne Diseases

ISSN

1877-959X

e-ISSN

—

Volume of the periodical

9

Issue of the periodical within the volume

4

Country of publishing house

DE - GERMANY

Number of pages

6

Pages from-to

844-849

UT code for WoS article

000433129600015

EID of the result in the Scopus database

2-s2.0-85044099359