Ixodes ricinus defensins attack distantly-related pathogens

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F15%3A00451345" target="_blank" >RIV/60077344:_____/15:00451345 - isvavai.cz</a>

Alternative codes found

RIV/60076658:12310/15:43888815

Result on the web

<a href="http://dx.doi.org/10.1016/j.dci.2015.08.001" target="_blank" >http://dx.doi.org/10.1016/j.dci.2015.08.001</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.dci.2015.08.001" target="_blank" >10.1016/j.dci.2015.08.001</a>

Result language

angličtina

Original language name

Ixodes ricinus defensins attack distantly-related pathogens

Original language description

Antimicrobial peptides are ubiquitous components of eukaryotic innate immunity. Defensins are a well-known family of antimicrobial peptides, widely distributed in ticks, insects, plants and mammals, showing activity against bacteria, viruses, fungi, yeast and protozoan parasites. Ixodes ricinus is the most common tick species in Europe and is a vector of pathogens affecting human and animal health. Recently, six defensins (including two isoforms) were identified in I. ricinus. We investigated the evolution of the antimicrobial activity of I. ricinus defensins. Among the five unique defensins, only DefMT3, DefMT5 and DefMT6 showed in vitro antimicrobial activity. Each defensin was active against rather distantly-related bacteria (P < 0.05), significantly among Gram-negative species (P < 0.0001). These three defensins represent different clades within the family of tick defensins, suggesting that the last common ancestor of tick defensins may have had comparable antimicrobial activity. D

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Developmental and Comparative Immunology

ISSN

0145-305X

e-ISSN

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Volume of the periodical

53

Issue of the periodical within the volume

2

Country of publishing house

GB - UNITED KINGDOM

Number of pages

8

Pages from-to

358-365

UT code for WoS article

000362138500009

EID of the result in the Scopus database

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