mRNA export in the apicomplexan parasite Toxoplasma gondii: emerging divergent components of a crucial pathway

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12310%2F18%3A43897459" target="_blank" >RIV/60076658:12310/18:43897459 - isvavai.cz</a>

Alternative codes found

RIV/60077344:_____/18:00491017

Result on the web

<a href="https://parasitesandvectors.biomedcentral.com/track/pdf/10.1186/s13071-018-2648-4" target="_blank" >https://parasitesandvectors.biomedcentral.com/track/pdf/10.1186/s13071-018-2648-4</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1186/s13071-018-2648-4" target="_blank" >10.1186/s13071-018-2648-4</a>

Result language

angličtina

Original language name

mRNA export in the apicomplexan parasite Toxoplasma gondii: emerging divergent components of a crucial pathway

Original language description

Control of gene expression is crucial for parasite survival and is the result of a series of processes that are regulated to permit fine-tuning of gene expression in response to biological changes during the life-cycle of apicomplexan parasites. Control of mRNA nuclear export is a key process in eukaryotic cells but is poorly understood in apicomplexan parasites. Here, we review recent knowledge regarding this process with an emphasis on T. gondii. We describe the presence of divergent orthologs and discuss structural and functional differences in export factors between apicomplexans and other eukaryotic lineages. Undoubtedly, the use of the CRISPR/Cas9 system in high throughput screenings associated with the discovery of mRNA nuclear export complexes by proteomic analysis will contribute to identify these divergent factors. Ligand-based or structure-based strategies may be applied to investigate the potential use of these proteins as targets for new antiprotozoal agents.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10608 - Biochemistry and molecular biology

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Parasites &amp; Vectors

ISSN

1756-3305

e-ISSN

—

Volume of the periodical

11

Issue of the periodical within the volume

JAN 25 2018

Country of publishing house

GB - UNITED KINGDOM

Number of pages

9

Pages from-to

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UT code for WoS article

000423448700004

EID of the result in the Scopus database

2-s2.0-85041491307