How the intracellular partitioning of tRNA and tRNA modification enzymes affects mitochondrial function

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12310%2F18%3A43897634" target="_blank" >RIV/60076658:12310/18:43897634 - isvavai.cz</a>
Alternative codes found
RIV/60077344:_____/18:00498788
Result on the web
<a href="https://iubmb.onlinelibrary.wiley.com/doi/epdf/10.1002/iub.1957" target="_blank" >https://iubmb.onlinelibrary.wiley.com/doi/epdf/10.1002/iub.1957</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/iub.1957" target="_blank" >10.1002/iub.1957</a>

Result language
angličtina
Original language name
How the intracellular partitioning of tRNA and tRNA modification enzymes affects mitochondrial function
Original language description
Organisms have evolved different strategies to seclude certain molecules to specific locations of the cell. This is most pronounced in eukaryotes with their extensive intracellular membrane systems. Intracellular compartmentalization is particularly critical in genome containing organelles, which because of their bacterial evolutionary ancestry still maintain protein-synthesis machinery that resembles more their evolutionary origin than the extant eukaryotic cell they once joined as an endosymbiont. Despite this, it is clear that genome-containing organelles such as the mitochondria are not in isolation and many molecules make it across the mitochondrial membranes from the cytoplasm. In this realm the import of tRNAs and the enzymes that modify them prove most consequential. In this review, we discuss two recent examples of how modifications typically found in cytoplasmic tRNAs affect mitochondrial translation in organisms that forcibly import all their tRNAs from the cytoplasm. In our view, the combination of tRNA import and the compartmentalization of modification enzymes must have played a critical role in the evolution of the organelle. (c) 2018 IUBMB Life, 70(12):1207-1213, 2018
Czech name
—
Czech description
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Type
Jimp - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10608 - Biochemistry and molecular biology

Project
<a href="/en/project/EF16_019%2F0000759" target="_blank" >EF16_019/0000759: Centre for research of pathogenicity and virulence of parasites</a>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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