Molecular regulations of metabolism during immune response in insects

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12310%2F19%3A43899417" target="_blank" >RIV/60076658:12310/19:43899417 - isvavai.cz</a>

Result on the web

<a href="https://reader.elsevier.com/reader/sd/pii/S0965174818304600?token=A33AA35F1A1639F903AC185CCE701318323901D0F57871069B719FB336E779C8477631D4AA394F8FFEAFFC7A954D8F57" target="_blank" >https://reader.elsevier.com/reader/sd/pii/S0965174818304600?token=A33AA35F1A1639F903AC185CCE701318323901D0F57871069B719FB336E779C8477631D4AA394F8FFEAFFC7A954D8F57</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.ibmb.2019.04.005" target="_blank" >10.1016/j.ibmb.2019.04.005</a>

Result language

angličtina

Original language name

Molecular regulations of metabolism during immune response in insects

Original language description

Mounting an immune response is an energy-consuming process. Activating immune functions requires the synthesis of many new molecules and the undertaking of numerous cellular tasks and it must happen rapidly. Therefore, immune cells undergo a metabolic switch, which enables the rapid production of ATP and new biomolecules. Such metabolism is very nutrient-demanding, especially of glucose and glutamine, and thus the immune response is associated with a systemic metabolic switch, redirecting nutrient flow towards immunity and away from storage and consumption by non-immune processes. The immune system during its activation becomes privileged in terms of using organismal resources and the activated immune cells usurp nutrients by producing signals which reduce the metabolism of non-immune tissues. The insect fat body plays a dual role in which it is both a metabolic organ, storing energy and providing energy to the rest of the organism, but also an organ important for humoral immunity. Therefore, the internal switch from anabolism to the production of antimicrobial peptides occurs in the fat body during infection. The mechanisms regulating metabolism during the immune response ensure adequate energy for an effective response (resistance) but they must be properly regulated because energy is not unlimited and the energy needs of the immune system thus interfere with the needs of other physiological traits. If not properly regulated, the immune response may-in the end decrease fitness via decreasing disease tolerance.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10608 - Biochemistry and molecular biology

Project

<a href="/en/project/GA17-16406S" target="_blank" >GA17-16406S: Origin of adenosine as a selfish immunity signal</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Insect Biochemistry and Molecular Biology

ISSN

0965-1748

e-ISSN

—

Volume of the periodical

109

Issue of the periodical within the volume

JUN 2019

Country of publishing house

GB - UNITED KINGDOM

Number of pages

12

Pages from-to

31-42

UT code for WoS article

000470192100004

EID of the result in the Scopus database

2-s2.0-85064119347