The highly diverged trypanosomal MICOS complex is organized in a nonessential integral membrane and an essential peripheral module
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12310%2F19%3A43901853" target="_blank" >RIV/60076658:12310/19:43901853 - isvavai.cz</a>
Alternative codes found
RIV/60077344:_____/19:00519416
Result on the web
<a href="https://boris.unibe.ch/133437/1/Eichenberger_et_al-2019-Molecular_Microbiology.pdf" target="_blank" >https://boris.unibe.ch/133437/1/Eichenberger_et_al-2019-Molecular_Microbiology.pdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/mmi.14389" target="_blank" >10.1111/mmi.14389</a>
Alternative languages
Result language
angličtina
Original language name
The highly diverged trypanosomal MICOS complex is organized in a nonessential integral membrane and an essential peripheral module
Original language description
The mitochondrial contact site and cristae organization system (MICOS) mediates the formation of cristae, invaginations in the mitochondrial inner membrane. The highly diverged MICOS complex of the parasitic protist Trypanosoma brucei consists of nine subunits. Except for two Mic10-like and a Mic60-like protein, all subunits are specific for kinetoplastids. Here, we determined on a proteome-wide scale how ablation of individual MICOS subunits affects the levels of the other subunits. The results reveal co-regulation of TbMic10-1, TbMic10-2, TbMic16 and TbMic60, suggesting that these nonessential, integral inner membrane proteins form an interdependent network. Moreover, the ablation of TbMic34 and TbMic32 reveals another network consisting of the essential, intermembrane space-localized TbMic20, TbMic32, TbMic34 and TbMic40, all of which are peripherally associated with the inner membrane. The downregulation of TbMic20, TbMic32 and TbMic34 also interferes with mitochondrial protein import and reduces the size of the TbMic10-containing complexes. Thus, the diverged MICOS of trypanosomes contains two subcomplexes: a nonessential membrane-integrated one, organized around the conserved Mic10 and Mic60, that mediates cristae formation, and an essential membrane-peripheral one consisting of four kinetoplastid-specific subunits, that is required for import of intermembrane space proteins.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10603 - Genetics and heredity (medical genetics to be 3)
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Molecular Microbiology
ISSN
0950-382X
e-ISSN
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Volume of the periodical
112
Issue of the periodical within the volume
6
Country of publishing house
US - UNITED STATES
Number of pages
13
Pages from-to
1731-1743
UT code for WoS article
000488620800001
EID of the result in the Scopus database
2-s2.0-85073968937