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The highly diverged trypanosomal MICOS complex is organized in a nonessential integral membrane and an essential peripheral module

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F19%3A00519416" target="_blank" >RIV/60077344:_____/19:00519416 - isvavai.cz</a>

  • Alternative codes found

    RIV/60076658:12310/19:43901853

  • Result on the web

    <a href="https://onlinelibrary.wiley.com/doi/pdf/10.1111/mmi.14389" target="_blank" >https://onlinelibrary.wiley.com/doi/pdf/10.1111/mmi.14389</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1111/mmi.14389" target="_blank" >10.1111/mmi.14389</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    The highly diverged trypanosomal MICOS complex is organized in a nonessential integral membrane and an essential peripheral module

  • Original language description

    The mitochondrial contact site and cristae organization system (MICOS) mediates the formation of cristae, invaginations in the mitochondrial inner membrane. The highly diverged MICOS complex of the parasitic protist Trypanosoma brucei consists of nine subunits. Except for two Mic10-like and a Mic60-like protein, all subunits are specific for kinetoplastids. Here, we determined on a proteome-wide scale how ablation of individual MICOS subunits affects the levels of the other subunits. The results reveal co-regulation of TbMic10-1, TbMic10-2, TbMic16 and TbMic60, suggesting that these nonessential, integral inner membrane proteins form an interdependent network. Moreover, the ablation of TbMic34 and TbMic32 reveals another network consisting of the essential, intermembrane space-localized TbMic20, TbMic32, TbMic34 and TbMic40, all of which are peripherally associated with the inner membrane. The downregulation of TbMic20, TbMic32 and TbMic34 also interferes with mitochondrial protein import and reduces the size of the TbMic10-containing complexes. Thus, the diverged MICOS of trypanosomes contains two subcomplexes: a nonessential membrane-integrated one, organized around the conserved Mic10 and Mic60, that mediates cristae formation, and an essential membrane-peripheral one consisting of four kinetoplastid-specific subunits, that is required for import of intermembrane space proteins.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10603 - Genetics and heredity (medical genetics to be 3)

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2019

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Molecular Microbiology

  • ISSN

    0950-382X

  • e-ISSN

  • Volume of the periodical

    OCT 2019

  • Issue of the periodical within the volume

    112

  • Country of publishing house

    GB - UNITED KINGDOM

  • Number of pages

    13

  • Pages from-to

    1731-1743

  • UT code for WoS article

    000488620800001

  • EID of the result in the Scopus database

    2-s2.0-85073968937