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Newly identified DNA methyltransferases of Ixodes ricinus ticks

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12310%2F20%3A43901177" target="_blank" >RIV/60076658:12310/20:43901177 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216224:14740/20:00115233

  • Result on the web

    <a href="https://www.sciencedirect.com/science/article/pii/S1877959X19301992?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S1877959X19301992?via%3Dihub</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1016/j.ttbdis.2019.101348" target="_blank" >10.1016/j.ttbdis.2019.101348</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Newly identified DNA methyltransferases of Ixodes ricinus ticks

  • Original language description

    DNA methylation at the fifth position of cytosine (5mC) and at the sixth position of adenine (6 mA) plays an important role in the regulation of the gene expression and, in eukaryotes, is essential for normal development. For Ixodes ricinus, the most common European arthropod vector of human and animal pathogens, the DNA methylation profile and the role of DNA methylation in tick development are still under discussion. Our goal was to analyze the status of I. ricinus DNA methylation at different life stages and identify enzymes that produce this type of DNA modification. We found that 5mC and 6mA are present in I. ricinus genomic DNA at all life stages. In the transcriptome of I. ricinus, we identified the sequences of the putative IrDNMT1, IrDNMT3, and IrDAMT enzymes, and bioinformatic analysis and three-dimensional modeling predicted their DNA methylation activity. This confirms that I. ricinus possesses a complete DNA methylation toolkit. Our results suggest that DNA methylation is important for the physiology and transstadial development of ticks.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10606 - Microbiology

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2020

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Ticks and Tick-borne Diseases

  • ISSN

    1877-959X

  • e-ISSN

  • Volume of the periodical

    11

  • Issue of the periodical within the volume

    2

  • Country of publishing house

    DE - GERMANY

  • Number of pages

    10

  • Pages from-to

  • UT code for WoS article

    000509982500020

  • EID of the result in the Scopus database

    2-s2.0-85076253184