Tick-Borne Encephalitis Virus Adaptation in Different Host Environments and Existence of Quasispecies

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12310%2F20%3A43901183" target="_blank" >RIV/60076658:12310/20:43901183 - isvavai.cz</a>

Alternative codes found

RIV/60077344:_____/20:00537498 RIV/00027162:_____/20:N0000105

Result on the web

<a href="https://www.mdpi.com/1999-4915/12/8/902" target="_blank" >https://www.mdpi.com/1999-4915/12/8/902</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/v12080902" target="_blank" >10.3390/v12080902</a>

Result language

angličtina

Original language name

Tick-Borne Encephalitis Virus Adaptation in Different Host Environments and Existence of Quasispecies

Original language description

A highly virulent strain (Hypr) of tick-borne encephalitis virus (TBEV) was serially subcultured in the mammalian porcine kidney stable (PS) andIxodes ricinustick (IRE/CTVM19) cell lines, producing three viral variants. These variants exhibited distinct plaque sizes and virulence in a mouse model. Comparing the full-genome sequences of all variants, several nucleotide changes were identified in different genomic regions. Furthermore, different sequential variants were revealed to co-exist within one sample as quasispecies. Interestingly, the above-mentioned nucleotide changes found within the whole genome sequences of the new variants were present alongside the nucleotide sequence of the parental strain, which was represented as a minority quasispecies. These observations further imply that TBEV exists as a heterogeneous population that contains virus variants pre-adapted to reproduction in different environments, probably enabling virus survival in ticks and mammals.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10607 - Virology

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2020

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Viruses - Basel

ISSN

1999-4915

e-ISSN

—

Volume of the periodical

12

Issue of the periodical within the volume

8

Country of publishing house

CH - SWITZERLAND

Number of pages

17

Pages from-to

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UT code for WoS article

000579648500001

EID of the result in the Scopus database

2-s2.0-85089798271