Full genome sequences and molecular characterization of tick-borne encephalitis virus strains isolated from human patients

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F15%3A00448150" target="_blank" >RIV/60077344:_____/15:00448150 - isvavai.cz</a>

Alternative codes found

RIV/00027162:_____/15:#0001273 RIV/60460709:41340/15:65007 RIV/60076658:12310/15:43888821 RIV/00216224:14310/15:00111738

Result on the web

<a href="http://dx.doi.org/10.1016/j.ttbdis.2014.09.002" target="_blank" >http://dx.doi.org/10.1016/j.ttbdis.2014.09.002</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.ttbdis.2014.09.002" target="_blank" >10.1016/j.ttbdis.2014.09.002</a>

Result language

angličtina

Original language name

Full genome sequences and molecular characterization of tick-borne encephalitis virus strains isolated from human patients

Original language description

Tick-borne encephalitis virus (TBEV) causes tick-borne encephalitis (TBE), one of the most important human neuroinfections across Eurasia. Up to date, only three full genome sequences of human European TBEV isolates are available, mostly due to difficulties with isolation of the virus from human patients. Here we present full genome characterization of an additional five low-passage TBEV strains isolated from human patients with severe forms of TBE. These strains were isolated in 1953 within Central Bohemia in the former Czechoslovakia, and belong to the historically oldest human TBEV isolates in Europe. We demonstrate here that all analyzed isolates are distantly phylogenetically related, indicating that the emergence of TBE in Central Europe was notcaused by one predominant strain, but rather a pool of distantly related TBEV strains. Nucleotide identity between individual sequenced TBEV strains ranged from 97.5% to 99.6% and all strains shared large deletions in the 3' non-coding re

Czech name

—

Czech description

—

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EE - Microbiology, virology

OECD FORD branch

—

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Ticks and Tick-borne Diseases

ISSN

1877-959X

e-ISSN

—

Volume of the periodical

6

Issue of the periodical within the volume

1

Country of publishing house

DE - GERMANY

Number of pages

9

Pages from-to

38-46

UT code for WoS article

000346222700005

EID of the result in the Scopus database

—