Novel BODIPY-subphthalocyanine dyads with reasonable photodynamic therapy behaviours
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12310%2F20%3A43901394" target="_blank" >RIV/60076658:12310/20:43901394 - isvavai.cz</a>
Result on the web
<a href="https://pubs.rsc.org/en/content/articlelanding/2020/NJ/D0NJ02455D#!divAbstract" target="_blank" >https://pubs.rsc.org/en/content/articlelanding/2020/NJ/D0NJ02455D#!divAbstract</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1039/d0nj02455d" target="_blank" >10.1039/d0nj02455d</a>
Alternative languages
Result language
angličtina
Original language name
Novel BODIPY-subphthalocyanine dyads with reasonable photodynamic therapy behaviours
Original language description
In this study, a set of bio-compatible and NIR emissive BODIPY-subphthalocyanine dyads (SP-DBD1-3) that contain amphiphilic triethyleneglycol units supporting partial water solubility and red absorbing BODIPY monomers (DBD1-3) were prepared. The photophysical and photochemical activities of these monomers, including fluorescence behaviors, singlet oxygen production, absorption, and emission profiles were investigated. The effect of the presence of halogen atoms and the BODIPY unit in dyads on the ability of generating singlet oxygen was evaluated. BODIPY-subphthalocyanine dyads showed two absorption bands at about 550 nm and 650 nm and high singlet oxygen quantum yields (up to 91%) at room temperature. The weaker fluorescence emissions, shorter fluorescence lifetimes but better singlet oxygen production capacities of dyads compared to those of BODIPY monomers have been explainedviathe energy transfer process from the donor subphthalocyanine unit to the acceptor BODIPY part, supporting ISC. Also,in vitrostudies underlined that the novel compounds (DBD1,DBD2,SP-DBD-2, andSP-DBD3) were successful in terms of the induction of cell death under red light; however, they did not affect the cells in dark, indicating these compounds as agents that can be used in photodynamic therapyin vivoin further studies.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10403 - Physical chemistry
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
New Journal of Chemistry
ISSN
1144-0546
e-ISSN
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Volume of the periodical
44
Issue of the periodical within the volume
32
Country of publishing house
GB - UNITED KINGDOM
Number of pages
7
Pages from-to
13738-13744
UT code for WoS article
000560486100026
EID of the result in the Scopus database
2-s2.0-85090110866