Characterization and functional analysis of cathelicidin-MH, a novel frog-derived peptide with anti-septicemic properties
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12310%2F21%3A43903292" target="_blank" >RIV/60076658:12310/21:43903292 - isvavai.cz</a>
Alternative codes found
RIV/60077344:_____/21:00554069
Result on the web
<a href="https://elifesciences.org/articles/64411" target="_blank" >https://elifesciences.org/articles/64411</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.7554/eLife.64411" target="_blank" >10.7554/eLife.64411</a>
Alternative languages
Result language
angličtina
Original language name
Characterization and functional analysis of cathelicidin-MH, a novel frog-derived peptide with anti-septicemic properties
Original language description
Antimicrobial peptides form part of the innate immune response and play a vital role in host defense against pathogens. Here we report a new antimicrobial peptide belonging to the cathelicidin family, cathelicidin-MH (cath-MH), from the skin of Microhyla heymonsivogt frog. Cath-MH has a single alpha-helical structure in membrane-mimetic environments and is antimicrobial against fungi and bacteria, especially Gram-negative bacteria. In contrast to other cathelicidins, cath-MH suppresses coagulation by affecting the enzymatic activities of tissue plasminogen activator, plasmin, beta-tryptase, elastase, thrombin, and chymase. Cath-MH protects against lipopolysaccharide (LPS)- and cecal ligation and puncture-induced sepsis, effectively ameliorating multiorgan pathology and inflammatory cytokine through its antimicrobial, LPS-neutralizing, coagulation suppressing effects as well as suppression of MAPK signaling. Taken together, these data suggest that cath-MH is an attractive candidate therapeutic agent for the treatment of septic shock.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
eLife
ISSN
2050-084X
e-ISSN
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Volume of the periodical
10
Issue of the periodical within the volume
APR 20 2021
Country of publishing house
GB - UNITED KINGDOM
Number of pages
23
Pages from-to
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UT code for WoS article
000642376100001
EID of the result in the Scopus database
2-s2.0-85105332922