Protease Inhibition-An Established Strategy to Combat Infectious Diseases
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12310%2F21%3A43903726" target="_blank" >RIV/60076658:12310/21:43903726 - isvavai.cz</a>
Alternative codes found
RIV/60077344:_____/21:00555025
Result on the web
<a href="https://www.mdpi.com/1422-0067/22/11/5762" target="_blank" >https://www.mdpi.com/1422-0067/22/11/5762</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/ijms22115762" target="_blank" >10.3390/ijms22115762</a>
Alternative languages
Result language
angličtina
Original language name
Protease Inhibition-An Established Strategy to Combat Infectious Diseases
Original language description
Therapeutic agents with novel mechanisms of action are urgently needed to counter the emergence of drug-resistant infections. Several decades of research into proteases of disease agents have revealed enzymes well suited for target-based drug development. Among them are the three recently validated proteolytic targets: proteasomes of the malarial parasite Plasmodium falciparum, aspartyl proteases of P. falciparum (plasmepsins) and the Sars-CoV-2 viral proteases. Despite some unfulfilled expectations over previous decades, the three reviewed targets clearly demonstrate that selective protease inhibitors provide effective therapeutic solutions for the two most impacting infectious diseases nowadays-malaria and COVID-19.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
International Journal of Molecular Sciences
ISSN
1422-0067
e-ISSN
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Volume of the periodical
22
Issue of the periodical within the volume
11
Country of publishing house
CH - SWITZERLAND
Number of pages
13
Pages from-to
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UT code for WoS article
000660180500001
EID of the result in the Scopus database
2-s2.0-85106658346