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Tick salivary gland transcriptomics and proteomics

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12310%2F21%3A43904218" target="_blank" >RIV/60076658:12310/21:43904218 - isvavai.cz</a>

  • Alternative codes found

    RIV/60077344:_____/21:00554304

  • Result on the web

    <a href="https://onlinelibrary.wiley.com/doi/10.1111/pim.12807" target="_blank" >https://onlinelibrary.wiley.com/doi/10.1111/pim.12807</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1111/pim.12807" target="_blank" >10.1111/pim.12807</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Tick salivary gland transcriptomics and proteomics

  • Original language description

    &apos;Omics&apos; technologies have facilitated the identification of hundreds to thousands of tick molecules that mediate tick feeding and play a role in the transmission of tick-borne diseases. Deep sequencing methodologies have played a key role in this knowledge accumulation, profoundly facilitating the study of the biology of disease vectors lacking reference genomes. For example, the nucleotide sequences of the entire set of tick salivary effectors, the so-called tick &apos;sialome&apos;, now contain at least one order of magnitude more transcript sequences compared to similar projects based on Sanger sequencing. Tick feeding is a complex and dynamic process, and while the dynamic &apos;sialome&apos; is thought to mediate tick feeding success, exactly how transcriptome dynamics relate to tick-host-pathogen interactions is still largely unknown. The identification and, importantly, the functional analysis of the tick &apos;sialome&apos; is expected to shed light on this &apos;black box&apos;. This information will be crucial for developing strategies to block pathogen transmission, not only for anti-tick vaccine development but also the discovery and development of new, pharmacologically active compounds for human diseases.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30102 - Immunology

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2021

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Parasite Immunology

  • ISSN

    0141-9838

  • e-ISSN

  • Volume of the periodical

    43

  • Issue of the periodical within the volume

    5

  • Country of publishing house

    GB - UNITED KINGDOM

  • Number of pages

    8

  • Pages from-to

  • UT code for WoS article

    000589525500001

  • EID of the result in the Scopus database

    2-s2.0-85096713443