Tick salivary gland transcriptomics and proteomics
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12310%2F21%3A43904218" target="_blank" >RIV/60076658:12310/21:43904218 - isvavai.cz</a>
Alternative codes found
RIV/60077344:_____/21:00554304
Result on the web
<a href="https://onlinelibrary.wiley.com/doi/10.1111/pim.12807" target="_blank" >https://onlinelibrary.wiley.com/doi/10.1111/pim.12807</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/pim.12807" target="_blank" >10.1111/pim.12807</a>
Alternative languages
Result language
angličtina
Original language name
Tick salivary gland transcriptomics and proteomics
Original language description
'Omics' technologies have facilitated the identification of hundreds to thousands of tick molecules that mediate tick feeding and play a role in the transmission of tick-borne diseases. Deep sequencing methodologies have played a key role in this knowledge accumulation, profoundly facilitating the study of the biology of disease vectors lacking reference genomes. For example, the nucleotide sequences of the entire set of tick salivary effectors, the so-called tick 'sialome', now contain at least one order of magnitude more transcript sequences compared to similar projects based on Sanger sequencing. Tick feeding is a complex and dynamic process, and while the dynamic 'sialome' is thought to mediate tick feeding success, exactly how transcriptome dynamics relate to tick-host-pathogen interactions is still largely unknown. The identification and, importantly, the functional analysis of the tick 'sialome' is expected to shed light on this 'black box'. This information will be crucial for developing strategies to block pathogen transmission, not only for anti-tick vaccine development but also the discovery and development of new, pharmacologically active compounds for human diseases.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30102 - Immunology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Parasite Immunology
ISSN
0141-9838
e-ISSN
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Volume of the periodical
43
Issue of the periodical within the volume
5
Country of publishing house
GB - UNITED KINGDOM
Number of pages
8
Pages from-to
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UT code for WoS article
000589525500001
EID of the result in the Scopus database
2-s2.0-85096713443