Telomerase as a possible key to bypass reproductive cost
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12310%2F23%3A43906490" target="_blank" >RIV/60076658:12310/23:43906490 - isvavai.cz</a>
Result on the web
<a href="https://onlinelibrary.wiley.com/doi/10.1111/mec.16870" target="_blank" >https://onlinelibrary.wiley.com/doi/10.1111/mec.16870</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/mec.16870" target="_blank" >10.1111/mec.16870</a>
Alternative languages
Result language
angličtina
Original language name
Telomerase as a possible key to bypass reproductive cost
Original language description
Three widely accepted assumptions are based on telomere research in human cells: (i) telomere length is a determinant of replicative ageing; (ii) telomerase activity in somatic cells supports the proliferative capacity of the cells and thus contributes to their regenerative potential and is a determinant of organismal lifespan; and (iii) the lack of telomerase activity acts as a tumour suppression mechanism. However, from a broader view, the link between telomere biology and cellular and organismal ageing, as well as tumour development, remains of debate, as I demonstrate with numerous examples of invertebrate and vertebrate species. Consequently, I propose a novel hypothesis that telomere biology, via somatic telomerase activity, reflects ageing rate from the perspective of species reproduction strategy.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10603 - Genetics and heredity (medical genetics to be 3)
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Molecular Ecology
ISSN
0962-1083
e-ISSN
1365-294X
Volume of the periodical
32
Issue of the periodical within the volume
9
Country of publishing house
US - UNITED STATES
Number of pages
10
Pages from-to
2134-2143
UT code for WoS article
000959131600001
EID of the result in the Scopus database
2-s2.0-85147930051