Identification of the photoproducts of the antidiabetic drug metformin and the different impact of metformin compared to its photoproducts mixture on aquatic organisms

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12310%2F25%3A43910128" target="_blank" >RIV/60076658:12310/25:43910128 - isvavai.cz</a>
Alternative codes found
RIV/62156489:43210/25:43927709
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S1382668925002406?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S1382668925002406?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.etap.2025.104865" target="_blank" >10.1016/j.etap.2025.104865</a>

Result language
angličtina
Original language name
Identification of the photoproducts of the antidiabetic drug metformin and the different impact of metformin compared to its photoproducts mixture on aquatic organisms
Original language description
Photochemical degradation of the antidiabetic drug metformin in the presence of a quinone sensitiser was investigated under environmentally relevant UV light. Degradation products were identified using UHPLC-QTOF. The effects of the resulting photoproduct mixture and metformin itself (50-100 mu g l-1) were assessed on four aquatic species representing different trophic levels: Desmodesmus subspicatus, Lemna minor, Daphnia magna and Danio rerio embryos. The photoproduct mixture caused growth inhibition in photosynthesising organisms, reproductive disruption in Daphnia, developmental malformations in fish embryos, and significant changes in oxidative stress markers. This study provides the first evidence that photochemically generated transformation products of metformin are significantly more toxic than the parent compound, even at environmentally relevant concentrations. These findings highlight the importance of including not only parent pharmaceuticals but also their photoproducts in environmental risk assessments, as the latter may pose a greater ecological hazard in surface waters.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10406 - Analytical chemistry

Project
<a href="/en/project/EF16_019%2F0000869" target="_blank" >EF16_019/0000869: Sustainable production of healthy fish in various aquaculture systems - PROFISH</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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