Effects of atorvastatin and its photoproducts on three trophic levels of the aquatic food web
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F25%3A00639285" target="_blank" >RIV/61388971:_____/25:00639285 - isvavai.cz</a>
Alternative codes found
RIV/60076658:12310/25:43909924 RIV/62156489:43210/25:43926863 RIV/62157124:16270/25:43882858
Result on the web
<a href="https://link.springer.com/article/10.1007/s13762-025-06551-w" target="_blank" >https://link.springer.com/article/10.1007/s13762-025-06551-w</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s13762-025-06551-w" target="_blank" >10.1007/s13762-025-06551-w</a>
Alternative languages
Result language
angličtina
Original language name
Effects of atorvastatin and its photoproducts on three trophic levels of the aquatic food web
Original language description
Atorvastatin (ATV) photodegradation with radiation relevant to the shortest solar radiation wavelengths reaching the Earth's surface was studied. Fourteen products of atorvastatin photodegradation (P-ATV) were identified by HPLC-HRMS/MS, chemical structures were proposed for twelve of them. The suggested structures include decarboxylated, dehydrated ATV, ether-like structures and phenanthrene-like byproducts. Toxicity assays revealed that exposure to ATV had a greater negative effect on the growth of the green algae Desmodesmus subspicatus than the exposure to P-ATV (IC20 values 140 mu g/l and 475 mu g/l, resp.). The opposite trend was observed with Daphnia magna where P-ATV was 12 times more toxic than ATV with LC50 values of 3.25 mg/l and 38.5 mg/l, resp.). Long-term exposure to environmental concentrations showed that P-ATV significantly lowered the number of juveniles of D. magna, while ATV had no effect. Neither ATV nor P-ATV affected the interclutch period or the number of clutches. The higher toxicity of P-ATV was observed also in the 96-h test with Danio rerio embryos (the determined LC50 values for ATV and P-ATV 5.56 mg/l and 2.74 mg/l, resp.). Both groups of embryos of D. rerio (exposed to ATV or P-ATV) showed malformations such as heart and yolk sac oedema with the more pronounced effect in P-ATV. The novelty of the study is in a significant contribution to the understanding of the photochemical degradation of atorvastatin under UV light conditions relevant to surface waters together with the demonstration of deleterious effects of photoproduct mixture on the selected aquatic organisms of different trophic levels.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10511 - Environmental sciences (social aspects to be 5.7)
Result continuities
Project
<a href="/en/project/EF16_019%2F0000869" target="_blank" >EF16_019/0000869: Sustainable production of healthy fish in various aquaculture systems - PROFISH</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
International Journal of Environmental Science and Technology
ISSN
1735-1472
e-ISSN
1735-2630
Volume of the periodical
22
Issue of the periodical within the volume
14
Country of publishing house
DE - GERMANY
Number of pages
16
Pages from-to
14293-14308
UT code for WoS article
001498492200001
EID of the result in the Scopus database
2-s2.0-105006825136