Modulation of antioxidant defence system in brain of rainbow trout (Oncorhynchus mykiss) after chronic carbamazepine treatment

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12520%2F10%3A00009994" target="_blank" >RIV/60076658:12520/10:00009994 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Modulation of antioxidant defence system in brain of rainbow trout (Oncorhynchus mykiss) after chronic carbamazepine treatment

Original language description

We investigated the effect of long-term exposure to carbamazepine (CBZ) on the antioxidant system in brain tissue of rainbow trout. Fish were exposed to sublethal concentrations of CBZ (1.0 ?g/l, 0.2 mg/l or 2.0 mg/l) for 7, 21, and 42 days. Oxidative stress indices (lipid peroxidation [LPO]) and carbonyl protein [CP]) and enzymatic antioxidants (superoxide dismutase [SOD], catalase [CAT], glutathione peroxidase [GPx], and glutathione reductase [GR]) in fish brain were measured. In addition, non-enzymatic antioxidant (reduced glutathione [GSH]) was determined after 42 days exposure. Carbamazepine exposure at 0.2 mg/l led to significant increases (p<0.05) of LPO and CP after 42 days and, at 2.0 mg/l, after 21 days. Activity of the enzymatic antioxidantsSOD, CAT, and GPx in CBZ-treated groups slightly increased during the first period (7 days). However, all measured antioxidant enzymes were significantly inhibited (p<0.05) at 0.2 mg/l exposure after 42 days and after 21 days at 2.0 mg/l

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

GL - Fishery

OECD FORD branch

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Project

<a href="/en/project/SP%2F2E7%2F229%2F07" target="_blank" >SP/2E7/229/07: Anthropogenic pressures on the status of soils, water resources and water ecosystems in the Czech part of the international basin of the Elbe River</a><br>

Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2010

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Comparative Biochemistry and Physiology C - Toxicology and Pharmacology

ISSN

1532-0456

e-ISSN

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Volume of the periodical

151

Issue of the periodical within the volume

1

Country of publishing house

US - UNITED STATES

Number of pages

5

Pages from-to

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UT code for WoS article

000273152400017

EID of the result in the Scopus database

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