Mass spectrometry: System based analysis?

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12520%2F10%3A43888485" target="_blank" >RIV/60076658:12520/10:43888485 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.3182/20100707-3-BE-2012.0040" target="_blank" >http://dx.doi.org/10.3182/20100707-3-BE-2012.0040</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3182/20100707-3-BE-2012.0040" target="_blank" >10.3182/20100707-3-BE-2012.0040</a>

Result language
angličtina
Original language name
Mass spectrometry: System based analysis?
Original language description
Correct interpretation of measurements from Liquid Chromatography in tandem with Mass Spectrometry (LC-MS) is mostly affected by presented noise. Noise additions are produced not only by random errors (random noise) but also by influence of mobile phase(systemic noise, baseline) from Liquid chromatography. Sum of the noise and signal may produce false interpretation or hide the signal under reasonable level. The LC-MS data are complex and algorithms based only on filtering in chromatographic domain (Total Ion Current - TIC) nor only in individual mass spectra can not have performance as good as algorithms which incorporate information from both domains together. Generally, filtration using hard fixed threshold values are problematic. Its results are often inconsistent between runs, instrumentation and methods because the values from nearest threshold neighborhood may be easily miss-classi fied. We proposed a novel method based on system approach to LC-MS data analysis. Because the pre
Czech name
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Czech description
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Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2010
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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