Modulations in androgen and estrogen mediating genes and testicular response in male goldfish exposed to bisphenol A

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12520%2F12%3A43883450" target="_blank" >RIV/60076658:12520/12:43883450 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1002/etc.1919" target="_blank" >http://dx.doi.org/10.1002/etc.1919</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/etc.1919" target="_blank" >10.1002/etc.1919</a>

Result language

angličtina

Original language name

Modulations in androgen and estrogen mediating genes and testicular response in male goldfish exposed to bisphenol A

Original language description

Adverse effects of bisphenol A (BPA) on reproductive physiology were studied in male goldfish (Carassius auratus) exposed to nominal environmentally relevant concentrations (0.2 and 20?mu g/L) for up to 90 d. Transcriptions of various reproductive geneswere measured in brain, liver, and testis to investigate the BPA modes of action. Volume, density, total number, motility, and velocity of sperm were measured to assess testicular function. At 0.2?mu g/L, BPA reduced steroidogenetic acute regulatory protein and increased estrogen receptors (ERs) messenger RNA (mRNA) transcript (ER beta 1 in liver and ER beta 2 in testis) after 90 d. At 20?mu g/L, BPA increased mRNA transcript of androgen receptor in testis, brain- and testis-specific aromatase, and vitellogenin in liver after 90, 30, 60, and 60 d, respectively. Transcripts of ERs mRNA were increased after 30 to 60 d at 20?mu g/L BPA; increase in ER beta 1 mRNA was observed in testis after 7 d. Total number, volume, and motility of sperm

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

GL - Fishery

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Environmental toxicology and chemistry

ISSN

0730-7268

e-ISSN

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Volume of the periodical

31

Issue of the periodical within the volume

9

Country of publishing house

US - UNITED STATES

Number of pages

9

Pages from-to

2069-2077

UT code for WoS article

000307938500020

EID of the result in the Scopus database

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