A rapid approach to assess estrogenic transcriptional activity of bisphenol A in the liver of goldfish
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12520%2F20%3AN0000001" target="_blank" >RIV/60076658:12520/20:N0000001 - isvavai.cz</a>
Result on the web
<a href="https://www.webofscience.com/wos/woscc/full-record/WOS:000600344000008" target="_blank" >https://www.webofscience.com/wos/woscc/full-record/WOS:000600344000008</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.22092/IJFS.2020.122798" target="_blank" >10.22092/IJFS.2020.122798</a>
Alternative languages
Result language
angličtina
Original language name
A rapid approach to assess estrogenic transcriptional activity of bisphenol A in the liver of goldfish
Original language description
Bisphenol A (BPA) is a synthetic compound widely used in types of consumer goods and medical tools. It has been shown that BPA acts as an endocrine disruptor chemical casuing negative impact on reproductive functions. The present study used an in vitro approach to assess estrogenic transcriptional activity of BPA as a rapid and sensitive method. The cultured pieces of hepatic tissue of goldfish (Carassius auratus) were exposed to 1, 5, 25 mu g L-1 BPA and 1 mu g L-1 E2 for comparison over 24 h. Compared to control, the mRNA transcript of er beta-I showed a significant increase in the hepatic tissues exposed to all doses of BPA and E-2. The mRNA transcript of er beta-II was signifincantly increased in hepatic tissues exposed to 1 and 5 mu g L-1 BPA and E-2. The mRNA transcripts of vtg in the hepatic tissues treated with 5 mu g L-1 BPA and E-2 were also increased, significantly. Finally, cyp 1a mRNA transcript showed a significant increase in the hepatic tissues exposed to 5 and 25 mu g L-1 BPA and E-2. These results show an estrogenic activity of BPA similar to E-2, and suggest that in vitro approach can be used as an alternative to in vivo test to detect estrogenic effects of BPA.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
40103 - Fishery
Result continuities
Project
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Continuities
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Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
IRANIAN JOURNAL OF FISHERIES SCIENCES
ISSN
1562-2916
e-ISSN
1562-2916
Volume of the periodical
19
Issue of the periodical within the volume
6
Country of publishing house
IR - IRAN, ISLAMIC REPUBLIC OF
Number of pages
16
Pages from-to
2877-2892
UT code for WoS article
000600344000008
EID of the result in the Scopus database
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