Di-(2-ethylhexyl)-phthalate disrupts pituitary and testicular hormonal functions to reduce sperm quality in mature goldfish

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12520%2F15%3A43888550" target="_blank" >RIV/60076658:12520/15:43888550 - isvavai.cz</a>
Result on the web
<a href="http://www.sciencedirect.com/science/article/pii/S0166445X15000910" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0166445X15000910</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.aquatox.2015.03.017" target="_blank" >10.1016/j.aquatox.2015.03.017</a>

Result language
angličtina
Original language name
Di-(2-ethylhexyl)-phthalate disrupts pituitary and testicular hormonal functions to reduce sperm quality in mature goldfish
Original language description
Di-(2-ethylhexyl) phthalate (DEHP) interferes with male reproductive endocrine system in mammals, however its effects on fish reproduction are largely unknown. We evaluated sperm quality and investigated reproductive endocrine system in mature goldfish (Carassius auratus) exposed to nominal 1, 10, and 100 mu g/L DEHP. To examine DEHP estrogenic activity, one group of goldfish was exposed to 17 beta-estradiol (5 mu g/L E-2) for comparison. Following 30 d of exposure, sperm production was decreased and suppressed in DEHP and E-2 treated goldfish, respectively. Sperm motility and velocity were decreased in goldfish exposed to 100 and 10 mu g/L DEHP at 15s post-sperm activation, respectively. Compared to control, 11-ketotestosterone (11-KT) levels were decreased at 10 and 1 mu g/L DEHP at day 15 and 30, respectively. In E-2 treated goldfish, 11-KT levels were decreased compared to control during the period of exposure. E-2 levels were increased in goldfish exposed to E-2, but remained unch
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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