Anti-androgen vinclozolin impairs sperm quality and steroidogenesis in goldfish

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12520%2F12%3A43883405" target="_blank" >RIV/60076658:12520/12:43883405 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/j.aquatox.2012.06.009" target="_blank" >http://dx.doi.org/10.1016/j.aquatox.2012.06.009</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.aquatox.2012.06.009" target="_blank" >10.1016/j.aquatox.2012.06.009</a>

Result language
angličtina
Original language name
Anti-androgen vinclozolin impairs sperm quality and steroidogenesis in goldfish
Original language description
In mammals, vinclozolin (VZ) is known as anti-androgen, which causes male infertility via androgen receptor (AR) antagonism. In aquatic animals, the VZ effects on reproductive functions are largely unknown and results are somewhat contradictory. To understand VZ adverse effects on male reproduction, mature goldfish (Carassius auratus) were exposed to three nominal VZ concentrations (100, 400, and 800 mu g/L) and alternations in gonadosomatic (GSI) and hepatosomatic indices (HSI), 17 beta-estradiol (E-2), 11-ketotestosterone (11-KT) and sperm quality were investigated compared to the solvent control. One group was exposed to E-2 (nominal concentration of 5 mu g/L), an estrogenic compound, as a negative control. Following one month exposure, GSI and HSIwere unchanged in all VZ treated groups compared to solvent control. Sperm volume, motility and velocity were reduced in fish exposed to 800 mu g/L VZ. This was associated with the decrease in 11-KT level, suggesting direct VZ effects on
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
GL - Fishery
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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